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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
28 articles
Newest firstBreast cancer is the most common cancer among women in the United States, and the leading cause of cancer incidence and mortality among Hispanic/Latina (H/L) women. For women with a genetic predisposition to hereditary breast and ovarian cancer (HBOC), genetic counseling has been shown to aid in the decision-making process and engagement in risk-reducing strategies for cancer prevention and early detection. Howeve…
Open article record in new tab ↗Cow milk and plant-based milk alternatives (PBMAs) are widely consumed beverages, yet both can act as pathways for exposure to environmental contaminants originating from soil, water, and legacy agricultural practices. In this study, we quantified heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), and arsenic (As)), macro- and micronutrients, and 24 organochlorine pesticides (OCPs) in cow milk and seven PBMAs (…
Open article record in new tab ↗Background Cannabis use is far more common among adults who smoke tobacco than adults who do not, and its use is increasing among people who smoke tobacco with children living in the home. Given the well-established evidence that caregiver smoking is the primary source of children's secondhand exposures to these products, the increasing trend in caregiver co-use is raising public health concerns about children's c…
Open article record in new tab ↗Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity. This study aimed to develop a practical risk score for SCRAs prevalent in Germany between 2013 and 2021, based on prevalence data and differentiated data on intox…
Introduction Abuse potential assessment of drugs with central nervous system activity is a critical component of the development of new medications for regulatory filings for approval worldwide. These new drug applications typically include recommendations for scheduling status as a controlled substance, if scheduling is warranted. This commentary focuses on the approach and current issues related to scheduling in…
Background and hypothesis Psychotic symptoms are common in adolescents and predictive of psychiatric disorders. Numerous risk factors have been shown to precede psychiatric disorders. However, investigating individual risk factors does not account for the cumulative effect these risk factors may have. Therefore, we combined well-researched environmental risk factors for psychotic disorder in a composite measure: t…
Background As marijuana use increases globally, understanding its cardiovascular impact is crucial. This study investigates the relationship between marijuana use patterns and coronary heart disease (CHD) risk. Methods Using 2023 Behavioral Risk Factor Surveillance System data, we conducted cross-sectional analysis examining marijuana consumption methods (smoking, vaping, eating, dabbing) and CHD risk. Multivariab…
Introduction The American Society for Gastrointestinal Endoscopy (ASGE) guidelines for common bile duct (CBD) stone management were created to risk stratify patients into low, intermediate, and high-risk groups to optimize interventions. Low-risk patients typically proceed to cholecystectomy with or without Intra-operative cholangiogram (IOC) whereas high-risk patients typically proceed to common duct clearance. T…
Open article record in new tab ↗In 2018, the Cannabis Act and its regulations established a strict legal framework for controlling production, distribution, sale and possession of cannabis across Canada. At that time, smoking dried cannabis was the most prevalent mode of consumption, and remains so to date, but cannabis vaping products have become increasingly popular since they were made commercially available in late 2019. Heavy metals are a r…
Open article record in new tab ↗Background The risks associated with medications and co-medications for chronic pain (CP) can influence a physician's choice of drugs and dosages, as well as a patient's adherence to the medication. High-quality care requires patients to participate in medication decisions. This study aimed to compare perceived risks of medications and co-medications between physicians and persons living with CP. Methods This cros…
BackgroundPeople with intellectual disabilities (ID) suffer higher rates of major osteoporotic fracture (MOF), including hip fracture (HF), at younger ages than the general population. We compared the cost-effectiveness of alternative fracture risk assessment strategies for people with ID aged [≥]40 years from a UK National Health Services perspective over a lifetime horizon. MethodsThree strategies were assessed:…
Open article record in new tab ↗Cannabidiol (CBD), a non-psychotropic main component of the Cannabis plant, has been approved as a drug in the European Union (EU) under the name "Epidyolex". However, its approval process as a food ingredient under the Novel Food Regulation was paused by the European Food Safety Authority (EFSA) due to a lack of safety data. Nevertheless, there is a growing, unregulated market in which CBD is advertised with vari…
Open article record in new tab ↗Background Studies on cannabis use and adverse cardiovascular outcomes have reported conflicting results. Research on its relationship to calcified arterial plaque remains limited. Methods Cross-sectional data from 2152 participants at Exam 6 (2016-2018) in the Multi-Ethnic Study of Atherosclerosis (MESA) were analyzed, including self-reported cannabis smoking patterns and carotid artery calcification (CAC) as mea…
Intimate partner violence (IPV) can include emotional, physical, or sexual violence. IPV during pregnancy is a preventable cause of injury and death with negative short- and long-term impacts for pregnant women, infants, and families. Using data from the 2016-2022 Pregnancy Risk Assessment Monitoring System in nine U.S. jurisdictions, CDC examined associations between IPV during pregnancy among women with a recent…
Abstract Introduction Amphetamine-type stimulants (ATSs) are becoming a growing concern in the West Bank. Despite the focus on marijuana, statistics show that ATS seizures and clandestine laboratories indicate increased use of this highly addictive chemical among Palestinians. Shifting from marijuana to ATS can have severe clinical and social consequences, yet insufficient studies have been conducted. Our study ai…
Open article record in new tab ↗BACKGROUNDChatGPT is a large language model with promising healthcare applications. However, its ability to analyze complex clinical data and provide consistent results is poorly known. This study evaluated ChatGPT-4s risk stratification of simulated patients with acute nontraumatic chest pain compared to validated tools. METHODSThree datasets of simulated case studies were created: one based on the TIMI score var…
Open article record in new tab ↗The safety of large language models (LLMs) as mental health chatbots is not fully established. This study evaluated the risk escalation responses of publicly available ChatGPT conversational agents when presented with prompts of increasing depression severity and suicidality. The average referral point to a human was at the midpoint of escalating prompts. However, most agents only definitively recommended professi…
Open article record in new tab ↗Introduction: Recent research claimed that CBD in commercial electronic cigarette (e-cigarette) liquids can be converted into psychotropic amounts of Δ9-THC. This study aims to validate this claim using a realistic e-cigarette setup. In addition, this study also investigates if such a conversion may occur during smoking of CBD-rich cannabis joints. Materials and Methods: Two different CBD liquids were vaporized us…
Gene drive technology promises to deliver on some of the global challenges humanity faces to-day in healthcare, agriculture and conservation. However, there is a limited understanding of the consequences of releasing self-perpetuating transgenic organisms into the wild populations under complex ecological conditions. In this study, we analyze the impact of three such complexities, mate-choice, mating systems and s…
Open article record in new tab ↗Endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and stone extraction is the treatment of choice for choledocholithiasis, reaching a successful clearance of the common bile duct (CBD) in up to 90% of the cases. Endoscopic ultrasound (EUS) has the best diagnostic accuracy for CBD stones, its sensitivity and specificity range being 89-94% and 94-95%, respectively. Traditionally seen as two s…
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