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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
15 articles
Newest firstIntroduction The use of medical cannabis products is expanding, yet real-world data on associated adverse events (AEs) remain limited. Controlled trials often exclude diverse patient populations and product types, making post-marketing surveillance essential to understanding cannabinoid safety. Objective The aim of this study is to characterize AEs reported by patients enrolled in the Minnesota Medical Cannabis Pr…
Open article record in new tab ↗Background With the increasing use of medical cannabis (MC), there is growing evidence suggesting that MC may be an effective therapeutic for chronic sleep, pain, and anxiety conditions. However, further evaluation is warranted to evaluate the heterogeneous patient outcomes of authorized cannabis treatment. Aims To assess the effectiveness of authorized cannabis on pain, sleep duration, anxiety, and depression in…
Open article record in new tab ↗BackgroundInfectious mononucleosis (IM) with hepatitis is associated with suppression of high-density lipoprotein cholesterol (HDL-C), but the magnitude, specificity, recovery kinetics, and long-term cardiovascular implications of this finding have not been systematically characterised. MethodsUsing the TriNetX Global Collaborative Network (>190 million patients, 178 healthcare organisations), we conducted a retro…
Open article record in new tab ↗PurposeWe evaluated healthcare resource utilization (HCRU) and costs in patients with eosinophilic granulomatosis with polyangiitis (EGPA). MethodsPatients with newly diagnosed EGPA (2017-2021), [≥]12 months pre-diagnosis health plan enrollment, and [≥]1 inpatient or [≥]2 outpatient claims with an EGPA diagnosis were included. Follow-up was from EGPA diagnosis until disenrollment or database end. HCRU and health i…
Background: Kidney transplant recipients (KTRs) have an increased risk for cardiovascular disease (CVD) and cerebrovascular disease (CBD). This study investigated the risks of CVD and CBD following kidney transplantation. Materials and methods: This retrospective cohort study enrolled 3596 KTRs between 2003 and 2017. Propensity Score Matching (PSM) was performed to select patients without a kidney transplant, who…
Introduction Chronic pain remains a challenge, with standard therapies often providing inadequate pain relief and causing undesirable side effects. Medicinal cannabis has emerged as promising alternative. This study assessed the impact of a cannabis hybrid extract on pain intensity and quality of life in daily clinical use. Methods ESCAPE was an observational study and included patients aged ≥ 18 years with chroni…
Objective Cannabis use has increased substantially worldwide, yet its association with inflammatory eye diseases remains poorly understood. This study evaluated whether cannabis users have higher risk of developing uveitis and related inflammatory ocular conditions compared to non-users. Methods We conducted a retrospective cohort study using the TriNetX Global Collaborative Network database. Adult patients with d…
BackgroundAI-powered digital front-door (DFD) tools are increasingly used to guide patients to appropriate care and alleviate healthcare system pressure. Yet, most evaluations narrowly assess triage accuracy or stated intent, offering limited insight into real-world behaviour and care appropriateness. MethodsThe ESSENCE study was a prospective, real-world quality improvement evaluation embedded in Portugals larges…
INTRODUCTIONWhile a vast amount of MRI data are collected for healthcare delivery, generating real-world evidence (RWE) in Alzheimers and related diseases (ADRD) research is substantially limited by lack of methods and results showing how routine MRIs can be used for ADRD imaging studies. METHODSWe compared three established ADRD biomarkers (total gray matter, hippocampal and ventricular volumes) in four groups (n…
Introduction Approximately 4% of the UK population experiences PTSD. Individuals must exhibit symptoms across four clusters to receive a diagnosis: intrusion, avoidance, altered reactivity, and altered mood. Evidence suggests that cannabinoid agonists such as nabilone and tetrahydrocannabinol (THC) may alleviate PTSD symptoms. We investigated the safety and effectiveness of THC-predominant cannabis flowers for inh…
Open article record in new tab ↗BackgroundRecent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use and hematological malignancy (HM). Nevertheless, the absolute rate difference is unclear due to the absence of cohort studies. MethodsWe extracted data from a territory-wide public healthcare database in Hong Kong to build a retrospective cohort of anonymized patients aged 18+ wi…
Open article record in new tab ↗Abstract Background Prediction of high-risk events in mental disorder patients is crucial. In our previous study, we developed a deep learning model: DeepBiomarker by using electronic medical records (EMR) to predict suicide related event (SRE) risk in post-traumatic stress disorder (PTSD) patients. Methods We applied DeepBiomarker2 through data integration of multimodal information: lab test, medication, co-morbi…
Background and hypothesis Schizophrenia and comorbid substance use disorders (SUDs) are associated with poor treatment outcomes but differences between the associations of different SUDs with clinical outcomes are poorly characterized. This study examines the associations of comorbid SUDs with clinical outcomes in schizophrenia using a largescale electronic health record (EHR) database. Design Real-world data (RWD…
Purpose Infertility is a topic of growing interest, and female infertility is often treated with gonadotropins. Evidence regarding comparative safety and efficacy of different gonadotropin formulations is available from clinical studies, while real-world data are missing. The present study aims to investigate effectiveness and safety of treatment with different gonadotropin formulations in women undergoing medical…
Introduction Insomnia diagnosis has been associated with a significant clinical and economic burden on patients and healthcare systems. This study examined changes in healthcare resource use (HCRU) and costs in insomnia patients before and after initiation of suvorexant treatment. Methods This retrospective cohort study analyzed Optum Clinformatics Data Mart claims data (Jan 2010-Dec 2018). Patients with ≥ 2 insom…