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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
13 articles
Newest firstRationale Negative affect is a key factor in Alcohol Use Disorder (AUD) associated with craving and relapse risk that is insufficiently treated by approved medications. Cannabidiol (CBD) has shown promising effects on negative affect, indicating its potential for addressing the neurocircuitry underlying negative affect in AUD. Objectives This study investigates CBD's effects on neural response to negative emotiona…
Open article record in new tab ↗Adaptive emotion regulation is essential for mental health. Reappraisal and acceptance are effective yet cognitively distinct emotion regulation strategies. A key unanswered question is whether their neural implementations are supported by common overarching or distinct neurofunctional processes, especially under dynamic, naturalistic conditions that mirror real-life scenarios. Here, we combined naturalistic fMRI…
Open article record in new tab ↗Background and hypothesis Affective instability (AffI) is associated with psychosis, and cannabis use is a known risk factor for psychosis. Previous evidence suggests that AffI may itself be a risk factor for cannabis use. This study aimed to investigate the longitudinal relationship between AffI and cannabis use during adolescence and the development of psychosis in early adulthood. Study design Data from the Avo…
Open article record in new tab ↗Rationale Cannabis use disorder (CUD) affects over 50 million people globally. Emerging evidence shows that some people with CUD may experience altered social cognition (e.g., emotion recognition or differentiation). These impairments can affect their ability to understand others' emotional states and navigate social interactions, potentially contributing to chronic cannabis use, even when it leads to interpersona…
Abstract Cannabis remains the most widely used illicit substance in the United States, specifically among young adults. Previous research identifies emotion dysregulation as a predictor of cannabis use, yet there remains some uncertainty in the literature regarding which facets of emotion dysregulation are the most important in relation to cannabis use. Indeed, the studies that have compared the facet-level associ…
Open article record in new tab ↗Rationale The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or other cannabinoid drugs can cause persistent adaptions in the endocannabinoid system and associated neural circuitry. It remains unclear how such treatments affect the way rewards are processed and pursued. Objective and methods We examined if repeated THC exposure…
Open article record in new tab ↗Novel psychoactive substances (NPS) are popular "club/party" drugs that first attracted attention in the UK in 2009 and remained legal until the 2016 Psychoactive Substances Act criminalized their distribution. Unlike "traditional" illicit drugs, very little is known about the influence of their analogs on neuropsychological functioning. We characterized the cognitive and emotional profile of NPS/polydrug users us…
Open article record in new tab ↗Cannabis use has been associated with anxiogenic effects when used in low frequency for a short duration, but cannabis can also have anxiogenic effects when used heavily for a long duration. Animal studies have indicated the neurobiological mechanisms related to cannabis and anxiety; however, research has been limited on the related neurocognitive mechanisms. Previous research has indicated that cannabis use is as…
Open article record in new tab ↗Background Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here, we investigate the effects of cannabis on listening to music, a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol, which may offset cannabis-related harms. Method…
Open article record in new tab ↗Fifteen years after the discovery of hypocretin/orexin a large body of evidence has been collected supporting its critical role in the modulation of several regulatory physiological functions. While reduced levels of hypocretin/orexin were initially associated with narcolepsy, increased levels have been linked in recent years to pathological states of hypervigilance and, in particular, to insomnia. The filing to F…
Open article record in new tab ↗Emerging evidence from both basic and clinical research demonstrates an important role for endocannabinoid (ECB) signaling in the processing of emotionally salient information, learning, and memory. Cannabinoid transmission within neural circuits involved in emotional processing has been shown to modulate the acquisition, recall, and extinction of emotionally salient memories and importantly, can strongly modulate…
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