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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
11 articles
Newest firstBackground/Objectives Corticobasal syndrome (CBS) shows weak clinicopathological correlation, with only half of cases attributable to corticobasal degeneration (CBD). Common alternative aetiologies include Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP). Emerging disease modifying therapies are likely to require accurate antemortem differentiation. While plasma biomarkers have potential, clinical…
Open article record in new tab ↗Plasma biomarkers have emerged as powerful tools to identify Alzheimers disease (AD) pathology and are increasingly used for diagnosis and monitoring. However, their wider differential diagnostic and prognostic value in neurodegenerative diseases other than AD remains unclear. This study tested and compared the diagnostic and prognostic performance of neurofilament light chain (NfL), p-tau217, A{beta}42/40 and GFA…
Open article record in new tab ↗Background Synaptic loss is characteristic of many neurodegenerative diseases; it occurs early and is strongly related to functional deficits. Objective In this longitudinal observational study, we determine the rate at which synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and we test the relationship with disease progression. Meth…
The relationship between in vivo synaptic density and molecular pathology in primary tauopathies is key to understanding the impact of tauopathy on functional decline and in informing new early therapeutic strategies. In this cross-sectional observational study, we determine the in vivo relationship between synaptic density and molecular pathology in the primary tauopathies of progressive supranuclear palsy and co…
Open article record in new tab ↗Novel psychoactive substances (NPS) are popular "club/party" drugs that first attracted attention in the UK in 2009 and remained legal until the 2016 Psychoactive Substances Act criminalized their distribution. Unlike "traditional" illicit drugs, very little is known about the influence of their analogs on neuropsychological functioning. We characterized the cognitive and emotional profile of NPS/polydrug users us…
Open article record in new tab ↗Background and aims Cannabis is a commonly used recreational drug in young adults. The worldwide prevalence in 18- to 25-year-olds is approximately 35%. Significant differences in cognitive performance have been reported previously for groups of cannabis users. However, the groups are often heterogeneous in terms of cannabis use. Here, we study daily cannabis users with a confirmed diagnosis of cannabis use disord…
Open article record in new tab ↗Objective Adolescence into young adulthood represents a sensitive period in which brain development significantly diverges by sex. Regular cannabis use by young people is associated with neuropsychological vulnerabilities, but the potential impact of sex on these relationships is unclear. Method In a cross-sectional study, we examined sex differences in multi-domain neuropsychological functioning using the Cambrid…
Understanding the cellular underpinnings of neurodegeneration remains a challenge; loss of synapses and dendritic arborization are characteristic and can be quantified in vivo, with [11C]UCB-J PET and MRI-based Orientation Dispersion Imaging (ODI), respectively. We aimed to assess how both measures are correlated, in 4R-tauopathies of progressive supranuclear palsy - Richardson's Syndrome (PSP-RS; n = 22) and amyl…
Open article record in new tab ↗The relationship between in vivo synaptic density and tau burden in primary tauopathies is key to understanding the impact of tauopathy on functional decline and in informing new early therapeutic strategies. In this cross-sectional observational study, we determine the in vivo relationship between synaptic density and molecular pathology, in the primary tauopathies of Progressive Supranuclear Palsy (PSP) and Cort…
Open article record in new tab ↗ABSTRACT Understanding the cellular underpinnings of neurodegeneration remains a challenge; loss of synapses and dendritic arborisation are characteristic and can be quantified i n vivo , with [ 11 C]UCB-J PET and MRI-based Orientation Dispersion Imaging (ODI), respectively. We aimed to assess how both measures are correlated, in 4R-tauopathies of Progressive Supranuclear Palsy (PSP-RS; n = 22) and amyloid-negativ…
Open article record in new tab ↗BackgroundSynaptic loss is a prominent and early feature of many neurodegenerative diseases. ObjectivesWe tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP-Richardsons syndrome) and amyloid-negative corticobasal syndrome (CBS). MethodsForty four participants (15 CBS, 14 PSP, and 15 age-/sex-/education-matched controls) underwent positron emissi…
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