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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
2 articles
Newest firstBackground/Objectives Corticobasal syndrome (CBS) shows weak clinicopathological correlation, with only half of cases attributable to corticobasal degeneration (CBD). Common alternative aetiologies include Alzheimer’s disease (AD) and progressive supranuclear palsy (PSP). Emerging disease modifying therapies are likely to require accurate antemortem differentiation. While plasma biomarkers have potential, clinical…
Open article record in new tab ↗Background Synaptic loss is characteristic of many neurodegenerative diseases; it occurs early and is strongly related to functional deficits. Objective In this longitudinal observational study, we determine the rate at which synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and we test the relationship with disease progression. Meth…