Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
11 articles
Newest firstAimsCOVID-19 and influenza continue to impose a substantial burden on the Canadian healthcare system, particularly among adults aged [≥]65 years. This study compared the clinical and economic outcomes of a "Stand-alone" vaccination strategy with separate influenza and COVID-19 vaccines versus a "Combination" strategy incorporating mRNA-1083, an investigational vaccine targeting both infections. MethodsThe study ad…
Open article record in new tab ↗BackgroundThe 2024-25 influenza season was the most severe in the United States (US) since 2017-18, with co-circulation of both influenza A virus subtypes (H1N1 and H3N2). Influenza vaccine effectiveness (VE) has varied by season, setting, and patient characteristics. MethodsUsing electronic healthcare encounter data from eight US states, we evaluated influenza vaccine effectiveness (VE) against influenza-associat…
BackgroundInfluenza vaccination reduces morbidity and mortality in older adults. This study identifies characteristics and reasons for vaccination uptake among the elderly to inform strategies to improve coverage. Methods: We conducted a cross-sectional survey in December 2024 among community-dwelling adults aged [≥]60 years across six Chinese cit-ies. Data collected included socio-demographic and health character…
Open article record in new tab ↗BackgroundAfter the prolonged COVID-19 pandemic, during which the seasonal influenza epidemic was suppressed, Japan experienced a record-breaking influenza A/H1N1 outbreak in the 2024/2025 season. This situation also raises a concern about the immunogenicity of the annual quadrivalent inactivated influenza vaccine (QIIV). This study evaluated post-vaccination hemagglutination inhibition (HI) antibody titers and th…
ObjectivesWe evaluated Nanopore sequencing for influenza surveillance. MethodsInfluenza A and B PCR-positive samples from hospital patients in Oxfordshire, UK, and a UK-wide population survey from winter 2022-23 underwent Nanopore sequencing following targeted rt-PCR amplification. ResultsFrom 941 infections, successful sequencing was achieved in 292/388(75%) available Oxfordshire samples: 231(79%) A/H3N2, 53(18%)…
Open article record in new tab ↗ObjectivesFever is common among individuals seeking healthcare after traveling to tropical regions. Despite the association with potentially severe disease, the etiology is often not determined. Cytokines are soluble mediators dynamically regulated in the response to infection. Measuring cytokines in the blood can therefore be informative to understanding the host-response to infection and can potentially indicate…
While there are numerous studies about influenza pandemic-associated school closures, literature is scant regarding closures associated with seasonal influenza. To address this knowledge gap, we conducted systematic daily online searches from August 1, 2011- June 30, 2022, to identify public announcements of unplanned school closures in the US lasting [≥]1 day, selecting those that mentioned influenza and influenz…
Open article record in new tab ↗Co-infection of COVID-19 and other respiratory pathogens, including influenza virus family, has been of importance since the beginning of the recent pandemic. As the upcoming flu season arrives in countries with ongoing COVID-19 epidemic, the need for preventive policy actions becomes more critical. We present a joint compartmental SEIRS-SIRS model for the co-circulation of SARS-CoV-2 and influenza and discuss the…
Open article record in new tab ↗Prior studies suggest that adverse events (AEs) following doses one and two of BNT162b2/Pfizer vaccine are worse in those with a prior history of COVID-19. To establish whether this outcome applies to a third/booster dose, we conducted a survey with 534 healthcare workers (HCW) in Northeast England, who reported AEs following all three doses of BNT162b2/Pfizer vaccine. We also explored AEs associated with concurre…
Open article record in new tab ↗We used primary and linked secondary healthcare data to investigate the incidence of clinically diagnosed influenza/influenza-like-illness (ILI) by ethnicity in England from 2008-2018. We identified higher incidence rate ratios for influenza/ILI among South Asian (1.70, 95% CI 1.66-1.75), Black (1.48, 1.44-1.53) and Mixed (1.22, 1.15-1.30) groups compared to White ethnicity. People from ethnic minority backgrounds…
Open article record in new tab ↗Estimation of epidemic onset timing is an important component of controlling the spread of seasonal infectious dis-eases within community healthcare sites. The Above Local Elevated Respiratory Illness Threshold (ALERT) algorithm uses a threshold-based approach to suggest incidence levels that historically have indicated the transition from endemic to epidemic activity. In this paper, we present the first detailed…