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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
10 articles
Newest firstBackgroundMpox, a zoonotic disease endemic to Africa, presents a significant public health threat with variable severity driven by viral clades and host factors. After over 50 years of outbreaks, this study aimed at providing a comprehensive continent-wide assessment of its severity and mortality for evidence-based public health planning and clinical management. MethodsThis systematic review and meta-analysis, con…
Open article record in new tab ↗BackgroundMpox remains a significant public health threat in Africa, with recent outbreaks driven by newly emergent clades I and II. Vaccination is a critical intervention for outbreak control, yet evidence on vaccine acceptance and uptake across the continent has not been comprehensively synthesized. This study aimed to determine the pooled prevalence and determinants of mpox vaccine acceptance and uptake in Afri…
Limited data exist on knowledge and attitudes towards mpox and the willingness to accept the mpox vaccine among vulnerable populations, such as people living with HIV and men who have sex with men (MSM), in countries facing intersecting HIV and mpox epidemics, like Nigeria. This study assessed the knowledge, attitudes, and willingness of these groups to receive the mpox vaccine in Rivers State. A cross-sectional s…
Open article record in new tab ↗BackgroundMpox remains a critical public health challenge in Central Africa, where endemic circulation of the virulent Clade I virus persists through zoonotic and human-to-human transmission. This systematic review and meta-analysis synthesize 40 years of evidence (1984-2024) to characterize Mpox epidemiology, vaccination gaps and clinical pattern in the Central African Republic (CAR), informing targeted control s…
BackgroundMpox, caused by the Mpox virus, is a zoonotic disease historically endemic in Central and West Africa. The Democratic Republic of Congo (DRC) bears the highest burden, with evolving epidemiology and significant public health challenges. Understanding severity and mortality trends is critical for global control efforts. MethodsThis systematic review and meta-analysis followed PRISMA guidelines to synthesi…
IntroductionIn September 2023, mpox clade 1b emerged in Kamituga, a mining zone in South Kivu, DR Congo, primarily through sexual transmission. This study investigates an mpox clade 1b outbreak in Uvira, 300 km from Kamituga, where the first case was reported in May 2024. MethodsFrom June-October 2024, clinical and household data from suspected mpox cases were collected at Uvira hospital and through investigations…
Open article record in new tab ↗BACKGROUNDThe expanding mpox outbreak in Africa and travel-associated cases in other continents have sparked efforts to expand vaccination. In this study and the accompanying report (Minhaj et al.), we assess the safety and long-term immunological response of MVA-BN vaccination. METHODSIn 2022, five years after the primary MVA-BN series, a third (booster) dose was administered to healthcare workers in the Democrat…
Open article record in new tab ↗BackgroundThe ongoing 2024 mpox outbreak in several African countries, driven by the novel Clade 1b strain, has resulted in imported cases being reported in Sweden and Thailand. The Asia Pacific (APAC) region, with little exposure to previous mpox waves, is particularly vulnerable to local transmission triggered by importation. While this highlights the importance of early preparedness, current knowledge of the vi…
Open article record in new tab ↗In an evolving infectious disease outbreak, there are two priorities: rapid and accurate detection of the causative agent and characterization of its spread. The polymerase chain reaction (PCR) assay is an effective and portable diagnostic method that can quickly provide information associated with virulence, transmissibility, and pathogenicity. Compared to genomic sequencing, PCR requires less infrastructure, fun…
Open article record in new tab ↗ImportanceSince May 2022, human monkeypox (mpox) infections have spread rapidly outside endemic countries. On July 23, 2023, WHO declared a Public Health Emergency of international Concern because of the unprecedented global spread of mpox. Whereas there is an incomplete understanding of transmission routes, the spread of monkeypox virus (MPXV) through sexual contact networks of men who have sex with men (MSM) hig…
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