Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
58 articles
Newest firstObjective The objective of this study was to examine whether cannabis exposure calls to the British Columbia Drug and Poison Information Centre (DPIC) were impacted by the legalization of non-medical cannabis in Canada. Methods We fit interrupted time series models to monthly counts of cannabis cases from 2013 to 2021, stratified by age and cannabis form. We set the intervention month to October 2018 legalization…
Open article record in new tab ↗Objective To assess the risk of infant exposure to illicit and prescription drug residues, from infant-ready, pooled, pasteurized donor human milk (PDHM) provided by healthy, screened, voluntary non-remunerated donors to a not-for-profit milk bank. Study design A total of 150 pooled samples, representing 742 donor contributions, were analyzed for 15 illicit and prescription drug analytes using liquid chromatograph…
Open article record in new tab ↗Prenatal tobacco (PTE) and tobacco cannabis co-exposure (PTCE) are associated with higher risk for child externalizing problems. However, developmental mechanisms for the PTE association and the PTCE related associations are poorly understood. We tested multiple mechanistic developmental pathways (emotion regulation, temperament, maternal negative mood, and continued postnatal tobacco exposure) from PTE and PTCE t…
Open article record in new tab ↗We describe the harmonisation of five UK electronic birth cohorts to the Observational Medical Outcomes Partnership (OMOP) Common Data Model, creating a large-scale, standardised resource for maternal and child health research. The Mother and Infant Research Data Analysis (MIREDA) partnership developed and implemented reproducible guidelines for mapping maternal-infant relationships and identifying pregnancy episo…
Background Cannabis use during pregnancy is becoming more prevalent. While numerous studies have explored the relationship of cannabis use during pregnancy and outcomes for mothers and infants, uncertainty remains regarding the impact of cannabis use on pregnancy complications and later-life outcomes for offspring. Aims To produce a summary of the short and long-term effects of prenatal cannabis exposure on fetal…
Background We analyzed the perioperative metabolomic alterations in children undergoing ventricular septal defect (VSD) repair under cardiopulmonary bypass (CPB), identified evidence of postoperative injury, and explored strategies to mitigate such injuries. Methods We conducted an untargeted metabolomic analysis of serum at three distinct time points (preoperative (Tp), immediate postoperative (T0), and 24 h post…
Open article record in new tab ↗A child died in the emergency room of a local hospital a few hours after ingesting a substance the color of cork and the consistency of earth. At home, a modest amount of resinous substance was found. At the hospital, the child exhibited alterations in walking, balance, and consciousness. Intubation was needed for the onset of dyspnea, so fentanyl and ketamine were administered during the procedure. A sample of bl…
Open article record in new tab ↗Bile duct perforation is a rare, serious complication of congenital biliary dilatation (CBD). While traditionally managed with a two-stage surgical approach, recent reports suggest that one-stage, minimally invasive approaches may be feasible. We present the case of a 13-month-old female who developed bile duct perforation associated with a protein plug in the common channel. Following the correction of coagulopat…
Background To investigate the association between prenatal illicit substance exposure and infant mortality, addressing the unclear links between specific and multiple substances and increased mortality. Methods This 16-year retrospective cohort study used Taiwan's National Health Insurance Research Database, the Taiwan Maternal and Child Health dataset, and the Integrated Illegal Drug Database, including 1 937 301…
Cannabinoid exposure in pediatric populations has become an increasing concern with the growing legalization and availability of cannabis products. While studies have addressed the clinical presentation of intoxication, limited data exist on child protection team (CPT) activation and child safety concerns in these cases. A 10-year retrospective study (2010-2021) was conducted at Hadassah Medical Center who operate…
Robot-assisted surgery is increasingly being utilized for congenital biliary dilatation (CBD); however, limited data exist on its feasibility across age groups, particularly for bile ductoplasty and intrapancreatic bile duct (IPBD) resection. This was a retrospective cohort study that compared the outcomes of robot-assisted versus laparoscopic CBD surgery in 159 patients (Rob group: 57; Lap group: 102) treated bet…
Importance The association between maternal medications and the macronutrient composition of human milk has not been studied. Objective To compare macronutrient levels in milk samples from mothers treated with long-term medications with samples from untreated healthy and disease-matched control mothers (DMCs). Design, setting, and participants A cross-sectional study using samples collected between October 2014 an…
Open article record in new tab ↗Background Congenital birth defects (CBDs) significantly affect child mortality and disability worldwide, yet regional understandings of their burden and contributing factors remain poorly defined. This study examines global trends in prevalence, disability-adjusted life years (DALYs), and mortality related to CBDs and their 11 subtypes from 1990 to 2021. Methods Employing data from the Global Burden of Disease St…
Objective This study aimed to analyze the choice of newly introduced antiseizure medications (ASMs; brivaracetam, cannabidiol, cenobamate, fenfluramine, and perampanel) by age and sex, and the use of these ASMs in relation to regulatory approval. Methods Patients were identified with dispensation of any ASM subsequent to at least one health care contact due to epilepsy (International Classification of Diseases, 10…
Open article record in new tab ↗Prenatal exposure to alcohol and tobacco has been associated with child regulatory abilities and problems, but less is known about the associations with cannabis exposure. This review seeks to address this gap primarily focusing on the effects of maternal cannabis use on the child. Thus, we investigate the association between pre- and postnatal cannabis exposure of the child and regulatory abilities and problems,…
Prenatal cannabis exposure (PCE) is of increasing concern globally, due to the potential impact on offspring neurodevelopment, and its association with childhood and adolescent brain development and cognitive function. However, there is currently a lack of research addressing the molecular impact of PCE, that may help to clarify the association between PCE and neurodevelopment. To address this knowledge gap, here…
Background Prenatal exposure to cannabis (or more specifically, delta 9-tetrahydrocannabinol [Δ9-THC]) has been consistently linked to low birthweight. Animal models further show that Δ9-THC is associated with rapid postnatal growth. Whether this association is modified by breastfeeding is unknown. Methods In this exploratory study, we followed 128 mother-child pairs through 3 years. Urinary Δ9-THC and cannabidiol…
Background Congenital biliary dilatation (CBD) is a prevalent congenital biliary disease in children, particularly in Asian populations, yet its etiology remains poorly understood. This study aimed to investigate the genome-wide DNA methylation profile in the peripheral blood of children with CBD to identify potential epigenetic mechanisms involved in its pathogenesis. Methods Genome-wide DNA methylation profiles…
Open article record in new tab ↗Background/purpose We evaluated the minimally invasive surgery for congenital biliary dilatation (CBD) in adults and children and analyzed the surgical outcomes, especially in children aged <6 years. Methods Characteristics and surgical outcomes of patients with CBD who underwent minimally invasive surgery at our hospital between 2013 and 2023 were retrospectively reviewed. Results Overall, 129 patients (89 childr…
Introduction This study investigated exposures involving ∆8-tetrahydrocannabinol (∆8-THC) reported to US poison centers (PCs), including variation among states and regions. It evaluated whether the ∆8-THC exposure rate was lower among states with ∆8-THC regulations and states where cannabis (∆9-THC) use was legal. Methods National Poison Data System data for ∆8-THC exposures in 2021-2022 were analyzed, including c…