Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
12 articles
Newest firstBackground An elevated risk of cardiovascular disease (CVD) and cerebrovascular disease (CBD) has been observed in patients with ICD-defined Neuromyelitis Optica (hereinafter referred to as NMO). However, population-based research on this topic remains limited. In this study, the risk of macrovascular events was compared between individuals with NMO and a matched population without NMO in Taiwan. Methods Data for…
Open article record in new tab ↗BackgroundReal-world data (RWD) from different countries are increasingly used to support regulatory, health technology assessment (HTA), and population-level evidence generation. However, cross-country analyses are challenged by differences in data provenance, healthcare systems, coding practices, completeness, and clinical workflows. The Observational Medical Outcomes Partnership (OMOP) common data model (CDM) i…
Background The cannabis control framework implemented by Canada in October 2018 established a robust post-market surveillance system for cannabis products, adopting tools and practices from the existing pharmacovigilance system for pharmaceuticals and health products. The cannabis vigilance system relies on spontaneous reporting of adverse reactions, allowing Health Canada to collect, monitor and assess health eff…
Open article record in new tab ↗IntroductionMedical cannabis use has expanded rapidly, yet long-term real-world safety data remain limited. We evaluated adverse-event (AE) frequency, severity, and predictors in a US telehealth registry of medical cannabis patients over one year. MethodsWe analyzed 14,313 adults who completed intake between June-August 2024. Patients reported any of 30 prespecified adverse events (AEs) and rated each on a 0-10 im…
Open article record in new tab ↗PurposeReal-world ocular imaging datasets are essential for advancing research in artificial intelligence (AI), autonomous disease screening, and clinical decision support. The Primary Eye Care dataset is a large-scale collection of de-identified retinal imaging data from routine optometric care, made available through the Institute for Digital Health (IDHea)--a secure research platform established by Topcon Healt…
INTRODUCTIONWhile a vast amount of MRI data are collected for healthcare delivery, generating real-world evidence (RWE) in Alzheimers and related diseases (ADRD) research is substantially limited by lack of methods and results showing how routine MRIs can be used for ADRD imaging studies. METHODSWe compared three established ADRD biomarkers (total gray matter, hippocampal and ventricular volumes) in four groups (n…
Background The aim of the current study was to examine patterns of medical cannabis use in those using it to treat anxiety and to investigate if the anxiolytic effects of cannabis were impacted by gender and/or age. Methods Patient-reported data (n = 184 participants, 61% female, 34.7 ± 8.0 years) was collected through the Strainprint® app. Tracked sessions were included if the method of administration was inhalat…
Open article record in new tab ↗This retrospective study utilized healthcare claims data to investigate the incidence, patient demographics, and concurrent diagnoses associated with long COVID in the U.S. Medicare population. Nearly 194,000 (0.6%) beneficiaries had post-COVID condition diagnoses, with higher rates among nursing home residents. Of those medically attended for COVID-19, 3-5% were diagnosed with post-COVID conditions. We observed m…
Open article record in new tab ↗Introduction: Clinical trials remain the gold standard for evaluating efficacy, but there is increasing interest in using real-world evidence (RWE) to inform health care decision making. The aims of this observational study were to describe patterns of medical cannabis use, associated changes in symptom severity over time, and to evaluate change in cannabis dose over time for pain-related symptoms. Methods: Data w…
Open article record in new tab ↗BackgroundData on effectiveness of sotrovimab preventing COVID-19-related hospitalization or mortality, particularly after the emergence of the Omicron variant, are limited. MethodDetermine the real-world clinical effectiveness of sotrovimab for prevention of 30-day COVID-19 related hospitalization or mortality using a retrospective cohort within the U.S. Department of Veterans Affairs (VA) healthcare system. Vete…
Open article record in new tab ↗Introduction: Despite increasing demand for data, little is known about the authorization patterns, safety, and effectiveness of medical cannabis products. Materials and Methods: We conducted a 2 year observational study of adult patients who were legally authorized a medical cannabis product from a single licensed producer; we captured and analyzed authorized cannabis use patterns by cannabinoid profile (tetrahyd…
With the medical use of cannabis permitted in Canada since 2001, patients seek to use this botanical drug to treat a range of medical conditions. However, many healthcare practitioners express the need for further scientific evidence around the use of medical cannabis. This real-world evidence study aimed to address the paucity of scientific data by surveying newly registered medical cannabis patients, before begi…
Open article record in new tab ↗