Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
6 articles
Newest firstAdaptive emotion regulation is essential for mental health. Reappraisal and acceptance are effective yet cognitively distinct emotion regulation strategies. A key unanswered question is whether their neural implementations are supported by common overarching or distinct neurofunctional processes, especially under dynamic, naturalistic conditions that mirror real-life scenarios. Here, we combined naturalistic fMRI…
Open article record in new tab ↗Oral cannabidiol (CBD) product use is increasing despite suboptimal pharmacokinetics (PK) of currently available formulations. This study aimed to investigate the PK of CBD formulated using the drug delivery technology DehydraTECH™, which is hypothesized to increase absorption by bypassing first-pass liver metabolism due to enhanced lipophilic composition. Anticonvulsant activity of the leading formulation was inv…
Open article record in new tab ↗Adaptive emotion regulation (ER) is essential for mental health. Reappraisal and acceptance are effective ER strategies that form the basis of therapeutic interventions, yet their common and distinct neural signatures - and the translational potential of these signatures - remain unclear. Here, we combined naturalistic fMRI with multivariate predictive modeling to develop neurofunctional signatures that accurately…
Background Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes of intervertebral disc (IVD) degeneration (IVDD). The pathogenesis of IVDD is complex and consists of inflammation, oxidative stress, and the loss of extracellular matrix (ECM). Cannabinoid type 2 receptor (CB2) has been shown to be involved in the pathological mechanism of a variety of diseases due to its anti-inflam…
BackgroundDeficient regulation of stress plays an important role in the escalation of substance use, addiction and relapse. Accumulating evidence suggests dysregulations in cognitive and reward-related processes and the underlying neural circuitry in cannabis dependence. However, despite the important regulatory role of the endocannabinoid system in the stress response, associations between chronic cannabis use an…
Open article record in new tab ↗The cannabinoid receptor-2 (CB2R) was initially thought to be the "peripheral cannabinoid receptor." Recent studies, however, have documented CB2R expression in the brain in both glial and neuronal cells, and increasing evidence suggests an important role for CB2R in the central nervous system inflammatory response. Intracerebral hemorrhage (ICH), which occurs when a diseased cerebral vessel ruptures, accounts for…
Open article record in new tab ↗