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Research included in this condition report
119 rights-cleared articles matching the governed report scope, ordered newest first.
119 articles
Newest firstObjectives Poor adherence to psychopharmacological treatment may contribute to relapses in bipolar disorder (BD). We performed a systematic review and meta-analysis to identify factors associated with poor adherence in BD. Methods The protocol was registered in Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/2KZFJ). We searched main electronic databases through March 2025. Random-effects meta-an…
Bipolar disorder (BD) is a severe psychiatric condition characterized by recurrent mood episodes and progressive neurobiological alterations associated with oxidative stress, mitochondrial dysfunction, and neuronal damage. Current pharmacological treatments remain limited by incomplete efficacy and significant adverse effects, highlighting the need for novel therapeutic strategies. The present study investigated t…
BACKGROUND: Despite the high prevalence of comorbid cannabis use at first onset of psychotic symptoms, high transition rates from cannabis-induced psychosis to schizophreniform psychoses and bipolar disorder, and evidence of cannabis use as a risk factor in developing primary psychosis, only a few studies have addressed the difficulties in differential diagnosis focusing on the early stages of the disease. AIMS: T…
Cannabis use is highly prevalent in individuals with psychosis, raising concerns about its influence on brain function. Electroencephalography (EEG) studies have identified alterations in brain activity in psychosis, including changes in spectral entropy (SE) modulation and connectivity strength (CS). However, the degree to which cannabis use contributes to these alterations remains unclear. This study investigate…
ObjectiveThe priorities of people with mental health challenges should be reflected in the research conducted on their behalf. Quantifying alignment of priorities with the unmet needs of people with lived experience is challenging, and to our knowledge, such alignment has not been extensively studied in bipolar disorder (BD). Natural language processing approaches comparing common topics derived from public forums…
Background and Clinical Significance: This report investigates the complex intersection of macrostructural neuroprotection and cortical hyperexcitability during long-acting atypical antipsychotic maintenance. We present a novel clinical case demonstrating an apparent absence of detectable cerebellar vermis atrophy progression during long-acting injectable (LAI) aripiprazole maintenance, which temporally coincided…
Schizophrenia and bipolar disorder are diagnostically distinct categories that overlap substantially in clinical features and genetic aetiology. Understanding genetic variants that contribute liability specifically to each disorder can offer insights into biological processes that differentiate them. Here we used Case-Case GWAS (CC-GWAS) to identify common genetic variants differentially associated with schizophre…
Cannabis use is widespread, with genetic differences partly explaining variation in individual patterns of use. We performed the largest-to-date genome-wide association study (GWAS) meta-analysis of cannabis ever-use (N=736,322, 76% European ancestry) and various measures of frequency of use (N=269,160 cannabis users, 84% European ancestry). We identified 54 independent genome-wide significant loci for ever-use an…
BackgroundDespite widespread recognition of the value of lived experience (LE) involvement in healthcare research and increased LE involvement activity, we lack established implementation methods and instruments for reporting and evaluating impact. We present a protocol for an innovative LE-led Impact Log tool and co-production framework, which may help to address some fundamental barriers to co-production. The Im…
Emerging evidence suggests that glucagon-like peptide-1 receptor (GLP1R) agonists may have potential benefits for mental illnesses. However, their exact effects remain unclear. This study investigated the causal relationship between glucagon-like peptide-1 receptor agonist (GLP1RA) and the risk of 10 common mental illnesses, including attention deficit and hyperactivity disorder, anorexia nervosa, anxiety disorder…
Background Understanding risk factors for violence in people with psychosis can inform risk management and violence prevention. However, much of the evidence comes from cross-sectional studies, and previous reviews require updating. Aims To synthesise evidence from longitudinal studies on risk factors for violence in people with schizophrenia-spectrum disorders, bipolar disorder or other affective psychoses. Metho…
Impaired decision-making is often seen in people with bipolar disorder (BD), even those undergoing treatment. Targeted therapeutics are therefore needed. People with BD report that cannabis use (CU) attenuates such cognitive and behavioral symptoms. We hypothesized that 1) people with BD who do not use cannabis would exhibit poor decision-making and functional capacity relative to healthy comparison (HC) participa…
Introduction The study aims to evaluate symptomatic differences through psychometric tools comparing patients in the early stages of psychotic development with those exhibiting a more established symptomatology. Our hypothesis was that the early phase in adolescent patients is accompanied by quantitatively and qualitatively distinct symptomatology compared to adults. Methods We assessed 116 participants-consisting…
Technological devices play a central role in adolescents' life. Despite concerns about negative effects of excessive screen time, there is little knowledge of screen behaviors' genetic architecture. Using self-reports from adolescents in the Norwegian Mother, Father, and Child Cohort Study (n = 18,490), we performed genome-wide association analysis for four screen behaviors: time spent (1) watching television; (2)…
BACKGROUND: The corpus callosum (CC) is a brain structure with a high heritability and potential role in psychiatric disorders. However, the genetic architecture of the CC and the genetic link with psychiatric disorders remain largely unclear. We investigated the genetic architectures of the volume of the CC and its subregions and the genetic overlap with psychiatric disorders. METHODS: We applied multivariate gen…
Background: Agitation is a frequent and challenging symptom in schizophrenia and bipolar disorder, characterized by heightened motor activity, emotional distress, and potential aggression. This symptom is most observed during acute episodes, representing a significant burden on patients, caregivers, and healthcare systems. Agitation is a leading cause of emergency department visits and psychiatric hospitalizations…
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with th…
Introduction Despite increasing legalization of medical cannabis across the U.S., significant barriers to access and utilization remain, particularly in states with restrictive policies. This study aimed to explore the patterns of medical cannabis use, methods of acquisition, perceived efficacy, and barriers to use, with a focus on how these factors vary by state-level legal status. Methods A cross-sectional, nati…
Background Mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD), are extensively studied regarding environmental risk factors, protective factors, peripheral biomarkers, and cognitive neurocognitive markers. Our umbrella review of observational studies aims to separately elucidate these associations with BD and MDD. Methods A comprehensive search of PubMed, Embase, Web of Science, an…