Loading articles…
Loading articles…
Research included in this condition report
164 rights-cleared articles matching the governed report scope, ordered newest first.
164 articles
Newest firstBackground Although current treatment guidelines recommend against cannabinoids for Post-Traumatic Stress Disorder (PTSD), their use has increased in clinical settings despite fragmented evidence. This review critically examines the efficacy, effectiveness, and safety of cannabinoid-based interventions for PTSD. Methods We conducted a scoping review following PRISMA-ScR guidelines. Five databases were searched up…
Rationale Traumatically injured individuals can develop chronic negative psychological sequelae. Improved understanding of contributing, peri-traumatic risk factors is essential to reduce the risk of these consequences. Previous studies have found that peri-traumatic, circulating endocannabinoid concentrations are positively associated with development of post-traumatic stress disorder (PTSD), chronic pain and dep…
Introduction Recent studies show that young females now report higher e-cigarette use than males, reversing prior trends. While sex differences in use are documented, little is known about underlying risk profiles. This study applied a machine learning (ML) approach to identify and compare predictors of adolescent e-cigarette use by sex. Methods We analyzed cross-sectional data from 1829 9th graders in Southern Ca…
Stress exposure has increased significantly, contributing to higher rates of anxiety, depression, and post-traumatic stress disorder. However, individual responses to stress vary greatly, underscoring the concept of stress resilience. The acute stress response activates the amygdala, hippocampus, and prefrontal cortex, stimulating the HPA axis and triggering cortisol release, which typically restores balance throu…
Endocannabinoids (eCBs) are lipid-derived neuromodulators that regulate numerous neurophysiological processes by modulating synaptic transmission. Synthesised on demand in response to increased postsynaptic intracellular calcium or activation of postsynaptic G-protein coupled receptors, eCBs are rapidly degraded, resulting in transient, tightly regulated signalling. Dysregulation in the endocannabinoid system (ECS…
The endocannabinoid ligand anandamide (AEA) plays a role in fear extinction, the conceptual foundation of the gold standard treatment for posttraumatic stress disorder (PTSD), exposure-based psychotherapy. Converging evidence from animal models and non-clinical human studies highlights the potential to enhance fear extinction pharmacologically by inhibiting the AEA catabolic enzyme, fatty acid amide hydrolase (FAA…
Objective This study examined whether cannabis expectancies mediate the relationship between lifetime cannabis use and symptoms of anxiety or depression among women who screened positive for post-traumatic stress disorder (PTSD). Method A total of 271 women completed an online survey assessing PTSD symptoms, lifetime cannabis use, anxiety and depression symptoms, and cannabis expectancies. Mediation analyses evalu…
The rising legal acceptance of cannabis and the high comorbidity between cannabis use disorder (CUD) and post-traumatic stress disorder (PTSD) highlight the importance of understanding how stress and cannabis influence the brain. We recently discovered that cannabinoid use promotes two PTSD-like symptoms: avoidance coping behaviors and the generalization of stress-coping responses to a neutral stimulus. Here, we u…
Background: War-related stressors can disrupt core beliefs and shape trauma outcomes, yet the distinct roles of moral processes in post-traumatic outcomes remain insufficiently understood.Objective: To examine how war-related stressors (WRS) and core-belief disruption (CBD) relate to posttraumatic stress disorder (PTSD) symptoms, moral injury (MI), moral sensitivity (MS), posttraumatic growth (PTG), and posttrauma…
Background With shifting perceptions about the therapeutic potential of cannabis and evolving regulatory frameworks, global prescribing of medicinal cannabis is increasing. While some emerging evidence supports its use for conditions like multiple sclerosis and epilepsy, its efficacy and safety profile for the treatment of mental health conditions remains controversial and under-explored. Previous reviews found in…
BackgroundEvidence on factors associated with cannabis for medical purposes (CMP) authorizations among Veterans Affairs Canada (VAC) clients remains limited and inconsistent, particularly concerning mental health and posttraumatic stress disorder (PTSD), a leading indication for use. We investigated demographic, clinical and service characteristics associated with VAC authorizations for CMP reimbursement. MethodWe…
Structured AbstractO_ST_ABSBackgroundC_ST_ABSPost-Traumatic Stress Disorder (PTSD) is a mental health condition affecting people who experience traumatic events. Trauma-exposed occupational groups report higher rates of PTSD than the general population. Current treatments, and access, often take months and may cause distress when people are required to talk about the trauma. ObjectiveTo determine the proof of conc…
BackgroundHealthcare workers are at increased risk of post-traumatic stress disorder (PTSD) due to prolonged exposure to high-stress clinical environments. Although the Health Belief Model (HBM) has been widely used to explain health behaviors, its application to psychological outcomes such as PTSD remains limited. The role of cognitive-emotional processes, particularly experiential avoidance, in linking health be…
AimsThe burden of common mental disorders (CMDs) is high in Kenya. Unfortunately, most Kenyans (75%) in need of mental healthcare cannot access these services. This study evaluates the feasibility, acceptability, and effectiveness of a brief, lay provider-delivered group-based psychological intervention - Group Problem Management Plus (gPM+) among adults with moderate symptoms of CMDs in a Kenyan urban informal se…
Abstract/SummaryTask-sharing approaches have shown promise in low-resource settings, yet few culturally adapted interventions have been systematically evaluated for forcibly displaced populations. Since 2016, over 1.7 million Venezuelans have migrated to Peru, facing significant barriers to healthcare and elevated risks of anxiety, depression, and post-traumatic stress disorder (PTSD). This protocol describes COMP…
Chronic pain is increasingly conceptualized within a stress-related framework. However, it remains unclear whether chronic pain and prototypical stress-related conditions—such as post-traumatic stress disorder (PTSD)—share common neurobiological substrates. To this end, we conducted a pre-registered transdiagnostic meta-analytic study of gray matter volume alterations in chronic pain (60 studies) and PTSD (20 stud…
Post-traumatic stress disorder (PTSD) is a severe mental health disorder with limited treatment options. Gold standard treatment includes cognitive behavioral therapies (CBT) that incorporate exposure to traumatic memories to facilitate extinction. CBT can be effective in PTSD, but effects are incomplete and symptoms are prone to spontaneous return. Pharmacologically facilitating fear extinction could potentiate t…
Post-traumatic stress disorder (PTSD) is a multidimensional illness that seldom occurs alone: roughly 80 % of patients also meet criteria for anxiety, depression, chronic pain, substance-use, eating or cognitive disorders. Converging genetic, neurochemical and behavioural findings implicate the neuropeptide S (NPS) system-acting through its G-protein-coupled NPS receptor (NPSR)-as a common regulator of these diver…
Background/Objectives: The co-occurrence of posttraumatic stress disorder (PTSD) and cannabis use disorder (CUD) symptoms is common following sexual assault, particularly among emerging adult women. CUD is associated with more severe PTSD symptoms and other mental health comorbidities including depression, suicidality, and emotion dysregulation. Addressing these issues concurrently soon after sexual assault could…
Background and objectives Individuals with posttraumatic stress disorder (PTSD) have an elevated risk of cannabis use disorder. However, the effect of cannabis legalization on use among individuals with PTSD is unclear. We evaluated changes in cannabis involvement in emergency department (ED) visits for PTSD after medical and nonmedical legalization in Ontario, Canada. Methods This repeated cross-sectional study u…