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Research Article 2026CC BYFree full text

Cannabinoid use generalizes stress responses: involvement of astrocyte plasticity and activation of matrix metalloproteinases in the nucleus accumbens core.

Ritchy Hodebourg, Lillian Duncan, Eric Dereschewitz, Peter Kalivas

The rising legal acceptance of cannabis and the high comorbidity between cannabis use disorder (CUD) and post-traumatic stress disorder (PTSD) highlight the importance of understanding how stress and cannabis influence the brain. We recently discovered that cannabinoid use promotes two PTSD-like symptoms: avoidance coping behaviors and the generalization of stress-coping responses to a neutral stimulus. Here, we u…

Molecular Psychiatry Europe PMC

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Research Article 2016CC BY-NCFree full text · non-commercial reuse

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.

Roberta Pennucci, Francesca Talpo, Veronica Astro, Valentina Montinaro, Lorenzo Morè, Marco Cursi +10 more

Rac GTPases regulate the development of cortical/hippocampal GABAergic interneurons by affecting the early development and migration of GABAergic precursors. We have addressed the function of Rac1 and Rac3 proteins during the late maturation of hippocampal interneurons. We observed specific phenotypic differences between conditional Rac1 and full Rac3 knockout mice. Rac1 deletion caused greater generalized hyperac…

Cerebral Cortex (New York, NY)