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Research included in this condition report
13 rights-cleared articles published in 2025, ordered newest first.
13 articles from 2025
Newest firstEmerging evidence suggests that glucagon-like peptide-1 receptor (GLP1R) agonists may have potential benefits for mental illnesses. However, their exact effects remain unclear. This study investigated the causal relationship between glucagon-like peptide-1 receptor agonist (GLP1RA) and the risk of 10 common mental illnesses, including attention deficit and hyperactivity disorder, anorexia nervosa, anxiety disorder…
Background Understanding risk factors for violence in people with psychosis can inform risk management and violence prevention. However, much of the evidence comes from cross-sectional studies, and previous reviews require updating. Aims To synthesise evidence from longitudinal studies on risk factors for violence in people with schizophrenia-spectrum disorders, bipolar disorder or other affective psychoses. Metho…
Impaired decision-making is often seen in people with bipolar disorder (BD), even those undergoing treatment. Targeted therapeutics are therefore needed. People with BD report that cannabis use (CU) attenuates such cognitive and behavioral symptoms. We hypothesized that 1) people with BD who do not use cannabis would exhibit poor decision-making and functional capacity relative to healthy comparison (HC) participa…
Introduction The study aims to evaluate symptomatic differences through psychometric tools comparing patients in the early stages of psychotic development with those exhibiting a more established symptomatology. Our hypothesis was that the early phase in adolescent patients is accompanied by quantitatively and qualitatively distinct symptomatology compared to adults. Methods We assessed 116 participants-consisting…
Technological devices play a central role in adolescents' life. Despite concerns about negative effects of excessive screen time, there is little knowledge of screen behaviors' genetic architecture. Using self-reports from adolescents in the Norwegian Mother, Father, and Child Cohort Study (n = 18,490), we performed genome-wide association analysis for four screen behaviors: time spent (1) watching television; (2)…
BACKGROUND: The corpus callosum (CC) is a brain structure with a high heritability and potential role in psychiatric disorders. However, the genetic architecture of the CC and the genetic link with psychiatric disorders remain largely unclear. We investigated the genetic architectures of the volume of the CC and its subregions and the genetic overlap with psychiatric disorders. METHODS: We applied multivariate gen…
Background: Agitation is a frequent and challenging symptom in schizophrenia and bipolar disorder, characterized by heightened motor activity, emotional distress, and potential aggression. This symptom is most observed during acute episodes, representing a significant burden on patients, caregivers, and healthcare systems. Agitation is a leading cause of emergency department visits and psychiatric hospitalizations…
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with th…
Introduction Despite increasing legalization of medical cannabis across the U.S., significant barriers to access and utilization remain, particularly in states with restrictive policies. This study aimed to explore the patterns of medical cannabis use, methods of acquisition, perceived efficacy, and barriers to use, with a focus on how these factors vary by state-level legal status. Methods A cross-sectional, nati…
Background Mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD), are extensively studied regarding environmental risk factors, protective factors, peripheral biomarkers, and cognitive neurocognitive markers. Our umbrella review of observational studies aims to separately elucidate these associations with BD and MDD. Methods A comprehensive search of PubMed, Embase, Web of Science, an…
Introduction: Social sustainability is deeply connected to the well-being of marginalized groups, and it is important to highlight how mental health impacts the social inclusion of homeless individuals, particularly veterans. Homelessness is a growing global issue, disproportionately affecting U.S. veterans, with mental health challenges playing a significant role in its onset and perpetuation. Purpose: This study…
Individuals with psychiatric disorders have significantly higher mortality rates than the general population. Despite identifying risk factors, few attempts have been made to systematically use this information to stratify mortality risk. To address this gap, we developed and externally validated a risk prediction model using national healthcare and social register data from two countries. Nationwide register data…
ObjectiveThis study aimed to estimate transition rates from substance-induced psychosis (SIP) to schizophrenia or bipolar disorder, evaluate the risk associated with dual use of methamphetamine and cannabis, and identify predictors of chronicity among Iranian men. MethodsA 25-year retrospective cohort study (1999-2024) was conducted using clinical data from Shafa Hospital, a tertiary psychiatric referral center in…