Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
7 articles
Newest firstCannabidiol (CBD) has gained significant attention for its potential therapeutic benefits, but its safety profile in healthy populations remains underexplored. This systematic review and meta-analysis aim to evaluate the safety of CBD compared to placebo in healthy adults. A comprehensive search of PubMed, Embase, Cochrane CENTRAL, and ClinicalTrials.gov identified four randomized controlled trials (RCTs) involvin…
Open article record in new tab ↗BackgroundDigital antimicrobial stewardship (AMS) interventions, such as clinical decision support systems, audit-and-feedback platforms, and electronic prescribing tools, have been increasingly adopted to improve antibiotic use. However, the effectiveness of these interventions across healthcare settings remains uncertain, and the certainty of the evidence has not been comprehensively evaluated. The objective of…
Open article record in new tab ↗Chronic low back pain (CLBP) affects over half a billion people worldwide. Current pharmacologic treatments offer limited efficacy and carry substantial risks, warranting the development of safe and effective alternatives. This multicenter, randomized, placebo-controlled phase 3 trial evaluated the efficacy and safety of VER-01 in CLBP. It enrolled 820 adults with CLBP (VER-01, n = 394; placebo, n = 426) and inclu…
Randomized controlled trials (RCTs) are the cornerstone of evidence-based healthcare, providing the most reliable means of assessing the efficacy and safety of health interventions. However, their rapidly growing volume and dispersion across diverse sources, such as bibliographic databases, preprint servers, and trial registries, pose major challenges for evidence synthesis, clinical guideline development, and hea…
Open article record in new tab ↗Background and ObjectiveRandomised controlled trials (RCTs) provide vital information about healthcare interventions. Accurate reporting is vital for effective RCT dissemination. This study aimed to assess the reporting quality of multi-country RCTs, using Ireland as a case study, examining trial characteristics, adherence to reporting standards and the reporting of participation from Ireland. Study Design and Set…
Substance use during pregnancy is associated with adverse pregnancy and neonatal outcomes; eHealth interventions offer a potential accessible treatment option. The objective of this systematic review and meta-analysis was to evaluate the effectiveness of eHealth interventions for the treatment of substance use during pregnancy. A comprehensive search of PsycINFO, Medline, CINAHL, Cochrane and Embase databases was…
Background Neuropathic pain (NeP), redefined as pain caused by a lesion or a disease of the somatosensory system, is a disabling condition that affects approximately two million Canadians. Objective To review the randomized controlled trials (RCTs) and systematic reviews related to the pharmacological management of NeP to develop a revised evidence-based consensus statement on its management. Methods RCTs, systema…