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19172026

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Author: Shin-ya Kawaguchi

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Brief Report 2026CC BYCC BY allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Depression of synaptic outputs by reduction of Ca2+ influx, but not RRP vesicles, becomes evident upon CB2R hyper-expression at cerebellar Purkinje cell terminals

Takuma Inoshita, Shin-ya Kawaguchi

Synaptic transmission is dynamically regulated by neuromodulators. One well-studied example is cannabinoid receptor type 1 (CB1R)-mediated suppression of neurotransmitter release by reducing presynaptic Ca2+ influx. Recently, GPR55 was shown to regulate transmitter release through a mechanism distinct from that of CB1R. However, the presynaptic role of cannabinoid receptor type 2 (CB2R) remains unclear. Here we st…

Frontiers in Molecular Neuroscience PubMed Central Open Access↗

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