The critical role of ion channels in kidney disease: perspective from AKI and CKD
Abstract Ion channels, particularly those in the transient receptor potential (TRP) family, play key roles in cellular stress responses like…
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Staphylococcus aureus AgrA Modulators From South African Antimicrobial Plants
Abstract South African plants are an underutilized metabolite source for novel antimicrobials targeting key quorum sensing (QS) systems like the…
Comprehensive pan-cancer analysis of CHRDL1 and experimental validation of its role in lung adenocarcinoma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-025-14174-0. Article type: Research Article Keywords: Chordin-like 1 (CHRDL1),…
Antibacterial Essential Oils as Adjuvants to Inhibit Antibiotic Resistance in Multidrug‐resistant Bacteria
Abstract In order to contribute to the fight against the antibiotic resistance crisis, we used a dual‐activity prospection strategy for…
PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-96562-x. Article type: Research Article Keywords: PKM2; prognosis, Tumor…
Impact of clinical factors on the diagnostic performance of diffuse optical spectroscopic imaging for breast cancer
Abstract Due to insufficient sensitivity of mammography in dense breasts, ultrasonography and MRI have been incorporated into breast screening, despite…
Epigenetic modulation of the NLRP6 inflammasome sensor as a therapeutic modality to reduce necroptosis-driven gastrointestinal mucosal dysfunction in HIV/SIV infection
Abstract Background: Gastrointestinal (GI) disease/dysfunction persists in people living with HIV (PLWH) receiving suppressive combination anti-retroviral therapy (ART) leading to…
Interplay between lipid profiles, thyroid function, and gallstone disease: A clinical perspective
Abstract Background: New research points to a complicated relationship between gallstone disease (GSD), thyroid function, and lipid profiles. To better…
Cannabidiol exerts teratogenic effects on developing zebrafish through the sonic hedgehog signaling pathway
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-99194-3. Article type: Research Article Keywords: Cannabidiol, Gastrulation period,…
Trends in burden and mortality of congenital birth defects in G20 countries (1990–2021) and predictions for 2022–2040
Abstract Objectives: Congenital birth defects (CBDs) rank among the top five causes of death in children under the age of…