GSK3β as a potential regulator in AML: A pan-cancer multi-omics analysis
Abstract The distinct roles of GSK3 isoforms (GSK3α/β) in tumorigenesis and immune modulation remain poorly characterized across malignancies. We integrated…
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Game Changers in the Treatment of and Engagement With Persons Living With Mental Health and Substance Use Disorders: The Role of the Nurse
Abstract The game changers in mental health and substance use disorder treatment have been shaped by historical sea changes marked…
Exposome involvement in the development of acne vulgaris
Abstract Acne vulgaris is one of the most prevalent chronic inflammatory skin diseases worldwide, characterized by marked clinical heterogeneity, fluctuating…
Multiple omics analyses and experiments validation identify PRDX3 as a biomarker of prognosis and antioncogene in kidney clear cell carcinoma
Abstract Peroxiredoxin 3 (PRDX3), a key mitochondrial redox enzyme, has been implicated in malignant tumor initiation and development. However, the…
Identification and Expression Analysis of the MLO Gene Family Under Salt Stress in Cotton (Gossypium hirsutum L.)
Abstract MLO (Mildew Resistance Locus O) genes encode seven-transmembrane proteins that function as critical regulators of powdery mildew resistance and…
Synthesis of Isochromans From Anacardic Acids Obtained From Cashew Nutshell Liquid (CNSL) and Their Antimicrobial Activity
Abstract The synthesis of racemic isochromans from cashew nut shell liquid (CNSL) derived anacardic acids is described. Two key steps…
Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy
Abstract Cannabis use during pregnancy continues to increase with smoking remaining the most common mode of consumption. While clinical studies…
A novel idiopathic transient tubulopathy associated with exercise-induced-seizures: A case report
Abstract First case of exercise-induced seizures linked to transient renal tubulopathy. Marked urinary sodium, potassium, and chloride loss without structural…
Artificial Intelligence in Public Health Education: A Scoping Review of Workforce Competency Development
Abstract Background: Artificial intelligence (AI) has catalyzed profound shifts in public health education, compelling institutions to explore innovative methods to…
In vitro antibacterial, anti-biofilm, anti-quorum-sensing, and cytotoxic activities of leaf crude extracts of Cannabis “Gorilla glue 1”
Abstract The resilience of biofilms makes it challenging to treat bacterial infections using conventional antibiotics. The study aimed to assess…
Effect of Δ9-tetrahydrocannabinol and cannabidiol on myofascial pain modulation in patients with temporomandibular disorder: a prospective crossover study
Abstract Δ9-THC/CBD reduced TMD pain from 7.35 to 3.50 on the VAS scale. Functional gain: mouth opening increased from 45.9…
Multi-dimensional analysis reveals the potential of PDK4 as a tumor biomarker and target for immunotherapy
Abstract Purpose: To explore the clinical significance of pyruvate dehydrogenase kinase 4 (PDK4) in pan-cancer and its potential as a…
Methamphetamine Use in People Living with HIV: Clinical, Neurocognitive, and Blood Biomarker Profiles
Abstract Background: Methamphetamine (MA) use in people living with HIV (PLWH) has been linked to neurocognitive and behavioral dysregulation. We…
Isolation, Antiradical Activity, and Cytotoxicity of Flavonoids From Cunila angustifolia
Abstract Cunila angustifolia (“vassourinha do campo”) is a plant species native to southern Brazil that is traditionally consumed as an…
Therapeutic Activities and Phytochemical Composition of Helianthus annuus L. Extracts
Abstract The sunflower (Helianthus annuus L.) is a plant commonly used in agriculture and the fuel industry, as well as…
Isoflavonoids and Epigenetic Modulation: Therapeutic Insights for Cancer Treatment
Abstract Isolavonoides represent the second largest subgroup of flavonoids and have an influence on critical molecular pathways and restore cellular…
BCTI: a Bayesian network-based method for revealing critical transitions in complex biological systems
Abstract Background: The identification of critical states during disease progression is essential yet challenging for preventing disease deterioration and developing…
Pan-cancer multi-omics profiling of OAS3 reveals its immunological and prognostic associations across human cancers
Abstract Background: The enzyme 2′-5′-oligoadenylate synthetase 3 (OAS3) plays a well-established role in antiviral immunity, but its involvement in cancer…