Comprehensive pan-cancer analysis of CHRDL1 and experimental validation of its role in lung adenocarcinoma

Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12885-025-14174-0. Article type: Research Article Keywords: Chordin-like 1 (CHRDL1), Cancer Prognostic Factors, Immune Cell Infiltration, Pan-cancer analysis Authors: Guangyin Ou, Tangke Gao, Shaopu Hu, Shuixiu Zhang, Shuo Song, Yue Sun, Ying Wang, Ruikang Zhong, Kaiwen Hu, Lei Gao, Min Jiang Affiliations: https://ror.org/05damtm70grid.24695.3c0000 0001 1431 9176Beijing University of Chinese Medicine, Beijing, China; https://ror.org/05damtm70grid.24695.3c0000 0001 1431 9176Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China; https://ror.org/02qxkhm81grid.488206.00000 0004 4912 1751The First Affiliated