Trends in burden and mortality of congenital birth defects in G20 countries (1990–2021) and predictions for 2022–2040
Abstract Objectives: Congenital birth defects (CBDs) rank among the top five causes of death in children under the age of…
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Medicinal plants trade in Harare’s urban markets: diversity, conservation status, and economic significance
Abstract Background: Urban markets serve as crucial centres for trading traditional medicinal plants, yet there is limited research on the…
Clinical and financial impact of a ‘difficult’ laparoscopic cholecystectomy
Abstract Background: Difficult intra‐operative findings during laparoscopic cholecystectomy (LC) may lead to poor clinical outcomes. This study aimed to compare…
The mechanism of YAP/TAZ transactivation and dual targeting for cancer therapy
Abstract Transcriptional coactivators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) play key roles in cancers through transcriptional…
Definitive urine drug testing in emergency medicine: Recreational and psychiatric drug findings
Abstract Definitive testing for recreational drugs in emergency medicine demonstrates clinical value. Presumptive immunoassay testing limits drug detection and has…
ADCYAP1 as a pan-solid cancer biomarker: predictor of immunotherapy efficacy in bladder cancer and prognostic potential across solid tumors
Abstract Background: ADCYAP1 has been identified with potential effects ranging from tumor growth activation to inhibition. However, it remains unknown…
The correction range of lumbosacral curve vertebral body tilt in degenerative scoliosis for achieving postoperative coronal balance
Abstract Purpose: To explore the relationship between lumbosacral curve vertebral body tilt correction and postoperative coronal balance in adult degenerative…
Cannabinoids and the Endocannabinoid System in the Treatment of Chronic Rhinosinusitis
Abstract Objective: Recently, the endocannabinoid system (ECS) has emerged as a therapeutic target for various inflammatory diseases, including those of…
Consensus Clinical Management Guideline for PLA2G6-Associated Neurodegeneration (PLAN)
Abstract This clinical guideline provides recommendations for the evaluation and management of individuals with PLA2G6-associated neurodegeneration (PLAN). PLAN, a neurodegeneration…
CBD-conjugated BMP-inhibiting exosomes on collagen scaffold dual-target Achilles tendon repair: Synergistic regeneration and heterotopic ossification prevention
Abstract Tendon injuries in the aging population are often complicated by heterotopic ossification (HO), hindering functional recovery. Exosomes from tendon…