Trends in burden and mortality of congenital birth defects in G20 countries (1990–2021) and predictions for 2022–2040

Abstract Objectives: Congenital birth defects (CBDs) rank among the top five causes of death in children under the age of five. Despite their significant impact, studies on the burden of CBDs in G20 countries remain limited. This study sought to examine the temporal trends in the disease burden and mortality rates of CBDs across G20 countries from 1990 to 2021, identify potential risk factors contributing to these trends, and project the disease burden and mortality rates for the period 2022–2040.