Impact of clinical factors on the diagnostic performance of diffuse optical spectroscopic imaging for breast cancer

Abstract Due to insufficient sensitivity of mammography in dense breasts, ultrasonography and MRI have been incorporated into breast screening, despite increasing false positive risks. While optical imaging has been suggested to improve specificity, its effectiveness in diagnosing breast lesions remains unclear. This study investigates the impact of clinical factors on the diagnostic performance of diffuse optical spectroscopic imaging (DOSI) for detecting breast malignancies. Between March and May 2022, 62 women with 62 breast lesions (37 malignant, 25 benign) were analyzed