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Research Article 2022CC BYFree full text

Concurrent tau pathologies in frontotemporal lobar degeneration with TDP-43 pathology.

Shunsuke Koga, Xiaolai Zhou, Aya Murakami, Cristhoper Fernandez De Castro, Matthew C. Baker, Rosa Rademakers +1 more

Aims Accumulating evidence suggests that patients with frontotemporal lobar degeneration (FTLD) can have pathologic accumulation of multiple proteins, including tau and TDP-43. This study aimed to determine the frequency and characteristics of concurrent tau pathology in FTLD with TDP-43 pathology (FTLD-TDP). Methods The study included 146 autopsy-confirmed cases of FTLD-TDP and 55 cases of FTLD-TDP with motor neu…

Neuropathology and Applied Neurobiology Europe PMC

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Article Commentary 2020CC BYFree full text

Commentary: LRP1 Is a Master Regulator of Tau Uptake and Spread.

Conor Fearon, Tim Lynch

Frontiers in Neurology Europe PMC

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Research Article 2015CC BY-NC-SAFree full text · non-commercial reuse

The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson's syndrome.

Keita Sakurai, Etsuko Imabayashi, Aya M Tokumaru, Shin Hasebe, Shigeo Murayama, Satoru Morimoto +4 more

Purpose Diagnosing corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is often difficult due to the wide variety of symptoms and overlaps in the similar clinical courses and neurological findings. The purpose of this study was to evaluate the utility of white matter (WM) atrophy for the diagnosis of patients with clinically diagnosed CBD (corticobasal syndrome, CBS) and PSP (Richardson's synd…