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Research Article 2024CC BYFree full text

Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer's disease and other neurodegenerative diseases.

Masanori Kurihara, Tomoyasu Matsubara, Satoru Morimoto, Akira Arakawa, Kensuke Ohse, Kazutomi Kanemaru +3 more

Recent studies suggest that increased cerebrospinal fluid (CSF) phospho-tau is associated with brain amyloid pathology rather than the tau pathology. However, confirmation using gold standard neuropathological assessments remains limited. This study aimed to determine background pathologies associated with aberrant CSF p-tau181 and amyloid-beta 1-42 (Aβ42) in Alzheimer's disease (AD) and other neurodegenerative di…

Acta Neuropathologica Communications Europe PMC

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Research Article 2015CC BY-NC-SAFree full text · non-commercial reuse

The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson's syndrome.

Keita Sakurai, Etsuko Imabayashi, Aya M Tokumaru, Shin Hasebe, Shigeo Murayama, Satoru Morimoto +4 more

Purpose Diagnosing corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is often difficult due to the wide variety of symptoms and overlaps in the similar clinical courses and neurological findings. The purpose of this study was to evaluate the utility of white matter (WM) atrophy for the diagnosis of patients with clinically diagnosed CBD (corticobasal syndrome, CBS) and PSP (Richardson's synd…