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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
24 articles
Newest firstThe complex and multifactorial nature of different neurodegenerative disorders hampers the capacity to identify effective treatments. Therefore, instead of relying solely on monotherapies or combination therapies, which typically come with dosing complications and limited synergy, multitarget-directed ligand strategies have emerged as one of the most dynamic and promising approaches to improve outcomes for such di…
Open article record in new tab ↗Cannabidiol (CBD), a major nonpsychoactive phytocannabinoid derived from Cannabis sativa L., has recently gained prominence for its broad pharmacological profile and emerging applications in regenerative medicine. Beyond its well-established neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti-inflammatory, analgesic, and anticancer effects, CBD has demonstrated the capacity to modulate key biological p…
Open article record in new tab ↗[This corrects the article DOI: 10.1021/acsomega.5c06420.].
Open article record in new tab ↗Ovarian cancer is the second leading cause of death from gynecologic malignancy worldwide. The integration of phytocannabinoids into oncological care has outpaced our mechanistic understanding of their interactions with frontline chemotherapeutics. In this study, we provide a detailed pharmacological evaluation of two phytocannabinoids, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as antineoplastic agents…
Open article record in new tab ↗In recent years, semisynthetic cannabinoids (SSCs) have emerged in commercial and illicit markets as alternatives designed to circumvent regulations targeting Δ9-tetrahydrocannabinol (Δ9-THC). However, their pharmacological properties, potency, and toxicological profiles remain poorly characterized, raising concerns about potential risks to consumers. In the present study, a liquid chromatography-tandem mass spect…
Open article record in new tab ↗Synthetic cannabinoids (SCs) are novel psychoactive substances (NPS) that are highly potent and associated with a range of severe toxicities. SC use, which is common in UK prisons and homeless communities, typically involves combustion of SC-soaked herb or paper material. Recently, e-cigarettes (or vapes) have emerged as popular delivery vehicles for SCs, and consumption among the general population has risen sign…
Open article record in new tab ↗Although chemotherapy regimens are well-established in clinical practice, chemoresistance and adverse side effects pose significant obstacles in cancer treatment. Paclitaxel (PTX), a widely used chemotherapeutic agent, faces formulation challenges due to its poor solubility and permeability. Research suggests that the phytochemical Cannabidiol (CBD) holds potential not only in targeting cancer cells but also in al…
Open article record in new tab ↗The endocannabinoid (eCB) system regulates several brain functions and is implicated in numerous conditions affecting the brain. Thus, the pharmacological blockade of cannabinoid receptors has a therapeutic potential but produces severe psychiatric side effects. Hence, new cannabinoid compounds with different pharmacological profiles are needed to potentially minimize this toxicity. The objective of this study, fe…
Open article record in new tab ↗Cannabis sativa L. is an ancient species that has been cultivated over the years for various applications, including recreational and medicinal use. Nowadays, the demand for its products has grown significantly, leading to an increase in the search for medicinal oils and a rise in smuggling, making it the main trafficked drug. In this context, our work optimized the extraction process of six cannabinoids in Cannab…
Open article record in new tab ↗Hemp is a lignocellulosic fiber used in fiber-reinforced composites, technical textiles, and clothing with surface properties that can be modified by plasma to improve processability. In contrast to previous studies reporting the effects of short-duration plasma treatment (<10 min), this paper investigates the effects of extended (30 min-4 h), low-pressure (∼0.4 mbar) argon and oxygen plasma treatments on dew rett…
Open article record in new tab ↗This study presents a novel analytical approach for classifying commercial hemp oil samples according to their Δ9-tetrahydrocannabinol (THC) content, employing mid-infrared (MIR) spectroscopy combined with machine learning algorithms. A total of 204 commercial hemp oil samples, with THC concentrations ranging from 0.0% to 16.6% w/w, were analyzed. Partial least-squares-discriminant analysis (PLS-DA) was employed f…
Open article record in new tab ↗The cannabinoid receptor type 2 (CB2R) is upregulated in the brain under pathological conditions. To distinguish between the healthy and disease states, Positron Emission Tomography (PET), as a noninvasive imaging technique, is employed, for which suitable highly affine and selective CB2R radioligands are required. The benzothiazole scaffold is a promising core structure that has been modified with different subst…
Open article record in new tab ↗This review synthesizes applications of inductively coupled plasma-mass spectrometry (ICP-MS) and hyphenated techniques for elemental determination in herbal medicines. The herbal medicine analysis has become increasingly important due to their widespread use in traditional and modern therapies. Due to the elements naturally present or contaminants (toxic elements) in herbal medicines and daily mineral requirement…
Open article record in new tab ↗Synthetic cannabinoids (SCs), a prominent class of new psychoactive substances, pose growing challenges to public health due to their severe toxic effects and widespread global presence. In this study, we employed computational methods to develop molecularly imprinted polymers (MIPs) for the selective recognition of seven SCs, chosen based on seizure reports from the Narcotics Examination Unit of the Scientific Po…
Open article record in new tab ↗With the recent legalization of cannabis in multiple jurisdictions and widespread use as a medical treatment, there has been an increased focus on product safety and the potential impacts of contaminants on human health. One factor that has received little attention is the possible exposure to potentially hazardous levels of toxic elements from rolling (smoking) papers. The elemental composition of rolling papers…
Open article record in new tab ↗Hemp has gained significant popularity for its diverse applications; however, this study explores the untapped potential of waste hemp (wH) as a cost-effective and sustainable bioadditive for the development of high-performance biocomposites. wH offers advantages such as low cost, easy availability, and suitability for extrusion. Polypropylene (PP) and poly(lactic acid) (PLA) served as polymer matrices for this in…
Open article record in new tab ↗In this work, we report a heterojunction formed by a PbS/CdS bilayer using the chemical bath deposition (CBD) technique because it is a relatively simple, fast, and low-cost technique; is permitted to obtain high-quality thin films (TFs); and also covers large areas. Some characterizations have been carried out to confirm the identity of the involved bilayer. For the cadmium sulfide (CdS) film, optical properties…
Open article record in new tab ↗The fire protection of carbon-fiber-reinforced polymer (CFRP) laminates often relies on flame-retardant coatings, but in some applications, their efficacy may diminish upon direct fire exposure due to rapid pyrolysis. This study introduces an innovative approach by integrating protective interlayers within the laminate structure to enhance the fire resistance. Various materials, including ceramic composite WHIPOX,…
Open article record in new tab ↗Tremendous progress has been made in determining the structures of G-protein coupled receptors (GPCR) and their complexes in recent years. However, understanding activation and signaling in GPCRs is still challenging due to the role of protein dynamics in these processes. Here, we show how dynamic nuclear polarization (DNP)-enhanced magic angle spinning nuclear magnetic resonance in combination with a unique pair…
Open article record in new tab ↗The investigation of high-efficiency and sustainable electrocatalysts for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in alkaline media is critical for renewable energy technologies. Here, we report a low-cost and high-yield method to obtain ZnOHF-ZnO-based 2D nanostars (NSs) by means of chemical bath deposition (CBD). The obtained NSs, cast onto graphene paper substrates, were used as ac…
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