Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
7 articles
Newest firstSemi-synthetic cannabinoids are a class of new psychoactive substances (NPSs) with structural similarities to the main psychoactive phytocannabinoid Δ9-tetrahydrocannabinol (Δ9-THC) found in Cannabis sativa L. The first semi-synthetic cannabinoids, which were used as legal substitutes for marijuana, were Δ8-tetrahydrocannabinol (Δ8-THC) and hexahydrocannabinol (HHC). Δ8-THC emerged around 2019 on the recreational…
Open article record in new tab ↗Introduction Binding affinity and functional potency are two distinct but pharmacologically related properties in ligand-receptor interactions. The molecular features influencing these two endpoints may differ, reflecting distinct physicochemical and conformational requirements for receptor binding and activation. Consequently, understanding the molecular features that determine both endpoints is essential, especi…
ABSTRACTWith increased sensitivity of instrumentation, more substances can be analysed using capillary dried blood spots (DBS), and therefore, minimal invasive sample collection can be performed. However, for cannabinoids such as (−)‐trans‐Δ9‐tetrahydrocannabinol (THC), low extraction efficiencies have been reported in previous studies. In this study, a novel extraction method was developed comprising an extractio…
Open article record in new tab ↗BackgroundDriving under the influence of cannabis is associated with impaired cognitive and psychomotor performance and an increased risk of traffic accidents. Reliable real-time in-vehicle systems for detecting cannabis-related driving impairment are currently lacking; but hold great potential for improving road safety. MethodsThis protocol describes the REVELIO test-track pilot study: a randomised, controlled, o…
Open article record in new tab ↗Tetrahydrocannabidiol (H4CBD) is an emerging semisynthetic cannabinoid, which has been known since 1940. Like hexahydrocannabinol (HHC), it is easily obtained by hydrogenation of available phytocannabinoids, in the case of H4CBD by hydrogenation of cannabidiol (CBD). H4CBD shows a weak affinity for the CB1 receptor, but it is unclear if H4CBD shows psychoactive properties, as reports from users are divided. Only a…
Open article record in new tab ↗After the Swiss ban of hexahydrocannabinol (HHC) in March 2023, other semisynthetic dibenzopyran cannabinoids emerged on the Swiss gray market. Hexahydrocannabiphorol (HHCP) was the most prominent of them due to its potent cannabimimetic effects, as anecdotal reports from recreational users suggest. In October 2023, a class wide ban of dibenzopyran cannabinoids was introduced in Switzerland to prevent new similar…
To investigate effects of smoking cannabidiol (CBD)-rich marijuana on driving ability and determine free CBD and Δ9-tetrahydrocannabinol (THC) concentrations in capillary blood samples, a randomised, double-blind, placebo-controlled, two-way crossover pilot study was conducted with 33 participants. Participants smoked a joint containing 500 mg of tobacco and either 500 mg of CBD-rich marijuana (16.6% total CBD; 0.…
Open article record in new tab ↗