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Research Article 2026CC BYFree full text

THC induced similar physiological effects on HIV transgenic rats and their controls without affecting HIV-induced deficits in effortful motivation.

Sunitha Vemuri, Samantha M Ayoub, Arpi Minassian, Jared W Young

Background Cannabinoids have proven to useful for attenuating adverse effects of HIV. People living with HIV use cannabis at higher rates, with evidence suggesting it alleviates physiological symptoms such as nausea, loss of appetite, etc.. Cannabis can alter physiology as well as essential behavioral functions such as motivation. This study investigated the effect of delta-9-tetrahydrocannabinol (THC), the main p…

Journal of Cannabis Research Europe PMC

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Research Article 2021CC BYFree full text

HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits.

Benjamin Z Roberts, Arpi Minassian, Adam L Halberstadt, Yinong V He, Muhammad Chatha, Mark A Geyer +2 more

Background HIV-associated neurocognitive disorder (HAND) is commonly observed in persons living with HIV (PWH) and is characterized by cognitive deficits implicating disruptions of fronto-striatal neurocircuitry. Such circuitry is also susceptible to alteration by cannabis and other drugs of abuse. PWH use cannabis at much higher rates than the general population, thus prioritizing the characterization of any inte…

International Journal of Neuropsychopharmacology Europe PMC

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