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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
7 articles
Newest firstObjectiveVentilator dyssynchrony (VD) is potentially harmful to patients with or at risk for acute respiratory distress syndrome (ARDS). In addition to injury solely caused by the ventilator, ventilator-induced lung injury may be instigated and exacerbated by patient respiratory efforts. Automated detection of VD from ventilator waveforms is challenging, and efforts have been made on a human-guided ML algorithm to…
Open article record in new tab ↗IntroductionObservational data enables large-scale vaccine safety surveillance but requires careful evaluation of potential sources of bias. One potential source of bias is an index date selection procedure for the unvaccinated cohort or unvaccinated comparison time. Here, we evaluate different index date selection procedures for two vaccines: COVID-19 and influenza. MethodsFor each vaccine, we extracted patient b…
Open article record in new tab ↗BackgroundRoutinely collected healthcare data such as administrative claims and electronic health records (EHR) can complement clinical trials and spontaneous reports when ensuring the safety of vaccines, but uncertainty remains about what epidemiological design to use. MethodsUsing 3 claims and 1 EHR database, we evaluate several variants of the case-control, comparative cohort, historical comparator, and self-co…
Open article record in new tab ↗Using real-world data and past vaccination data, we conducted a large-scale experiment to quantify bias, precision and timeliness of different study designs to estimate historical background (expected) compared to post-vaccination (observed) rates of safety events for several vaccines. We used negative (not causally related) and positive control outcomes. The latter were synthetically generated true safety signals…
Open article record in new tab ↗Structured AbstractO_ST_ABSImportanceC_ST_ABSPost-acute sequelae of SARS-CoV-2 infection (PASC) is emerging as a major public health issue. ObjectiveWe characterized the incidence of PASC, or related symptoms and diagnoses, for COVID-19 and influenza patients. DesignRetrospective cohort study. SettingOur data sources were the IBM MarketScan Commercial Claims and Encounters (CCAE), Optum Electronic Health Record (E…
Open article record in new tab ↗PurposeWe aimed to describe the demographics, cancer subtypes, comorbidities and outcomes of patients with a history of cancer with COVID-19 from March to June 2020. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza. MethodsWe conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, stan…
Open article record in new tab ↗BackgroundIn this study we phenotyped individuals hospitalised with coronavirus disease 2019 (COVID-19) in depth, summarising entire medical histories, including medications, as captured in routinely collected data drawn from databases across three continents. We then compared individuals hospitalised with COVID-19 to those previously hospitalised with influenza. MethodsWe report demographics, previously recorded…
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