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Research Article 2019CC BYFree full text

Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE.

Lukas Mogler, Sebastian Halter, Maurice Wilde, Florian Franz, Volker Auwärter

Purpose 5F-CUMYL-PEGACLONE is a recently emerged γ-carbolinone derived synthetic cannabinoid. The present study aimed to identify phase I metabolites to reliably prove consumption of the substance by urine analysis and to differentiate from the uptake of the non-fluorinated analog CUMYL-PEGACLONE. Methods For metabolite characterization, phase I metabolites were analyzed by liquid chromatography-high resolution ma…

Forensic Toxicology Europe PMC

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Research Article 2018CC BYFree full text

5F-Cumyl-PINACA in 'e-liquids' for electronic cigarettes: comprehensive characterization of a new type of synthetic cannabinoid in a trendy product including investigations on the in vitro and in vivo phase I metabolism of 5F-Cumyl-PINACA and its non-fluorinated analog Cumyl-PINACA.

Verena Angerer, Florian Franz, Bjoern Moosmann, Philippe Bisel, Volker Auwärter

Purpose In recent years e-liquids used in electronic cigarettes have become an attractive alternative to smoking tobacco. A new trend is the use of e-liquids containing synthetic cannabinoids (SCs) instead of smoking cannabis or herbal mixtures laced with SCs. In the frame of a systematic monitoring of the online market of 'legal high' products, e-liquids from online retailers who also sell herbal blends were boug…

Forensic Toxicology PubMed Central Open Access