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Research Article 2025-09-27CC BYFree full text

Discriminating the prodromal stage of multiple sclerosis using longitudinal health administrative claims data and machine learning-based sequence analysis

Ondřej Klempíř, Martina Holá, Martin Rožánek, Juliana Grand Müllerová, Aleš Tichopád

BackgroundMultiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system. Early detection of the prodromal phase could enable timely interventions to potentially modify disease progression. This study leverages longitudinal health administrative claim (HAC) data to identify patterns distinguishing the prodromal stage of MS from other neurological conditions. MethodsHAC data from the Czech He…

medRxiv medRxiv

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Research Article 2024-06-01CC0Free full text

Medical Costs, Health Care Utilization, and Productivity Losses Associated With Hypertension by COVID-19 Among US Commercial Enrollees

Jun Soo Lee, Yidan (Xue) Zhang, Yu Wang, Joohyun Park, Ashutosh Kumar, Bruce Donald +2 more

BackgroundHypertension is a major risk factor for cardiovascular and renal diseases, significantly contributing to morbidity and mortality. The COVID-19 pandemic has heightened concerns about the impact of hypertension on severe COVID-19 outcomes. MethodsWe conducted a cross-sectional analysis using the 2021 MarketScan Commercial and Health and Productivity Management databases. The study included adults aged 18-6…

medRxiv

Research Article 2023-01-26CC BY-NCFree full text · non-commercial reuse

General practitioners ending their practice and impact on patients' health, health care use and mortality. A protocol for national registry cohort studies in Norway, 2006 to 2021.

Kristin Hestmann Vinjerui, Kjartan Sarheim Anthun, Andreas Asheim, Fredrik Carlsen, Bente Prytz Mjølstad, Sara Marie Nilsen +2 more

IntroductionContinuous general practitioner (GP) and patient relations associate with positive health outcomes. Termination of GP-practice is unavoidable, while consequences of final breaks in relations are less explored. We will study how an ended GP-relation affects patients health care utilization and mortality, compared to patients with a continuous GP-relation. Methods and analysisLinking personal-level natio…

medRxiv

Research Article 2022-09-22CC BYFree full text

Multimorbidity and its associated factors in Indonesia through universal health coverage scheme: A cross-sectional study based on national claims data

Noor Afif Mahmudah, Mesfin Kassaye Tessma, Yodi Mahendradhata

Multimorbidity has been increasing globally and is usually associated with higher health care utilization and costs. Indonesia has been implementing Universal Health Coverage (UHC) program since 2014. However, there is a limited study of the prevalence of multimorbidity and its impact on health care utilization and costs through the UHC scheme in Indonesia. This study aimed to determine the prevalence of multimorb…