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Research Article 2024-09-19CC BYFree full text

Cohort profile: design, sociodemographic characteristics, chronic disease risk factors, and baseline hypertension and diabetes care cascades of the open, prospective Community-Based chronic disease Care Lesotho (ComBaCaL) cohort

Felix Gerber, Giuliana Sanchez-Samaniego, Thesar Tahirsylaj, Thabo Ishmael Lejone, Tristan Lee, Fabian Raeber +28 more

PurposeThe open, prospective Community-Based chronic Care Lesotho (ComBaCaL) cohort is the first study to comprehensively investigate socioeconomic indicators, common chronic diseases and their risk factors in a remote rural setting in Lesotho. It serves as a platform for implementing nested trials using the Trials within Cohorts (TwiCs) design to assess community-based chronic care interventions. Here, we present…

medRxiv medRxiv

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Research Article 2019CC BYFree full text

Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats.

Rafał Kossakowski, Eberhard Schlicker, Marek Toczek, Jolanta Weresa, Barbara Malinowska

Cannabidiol (CBD) is a nonpsychotropic constituent of Cannabis sativa L. It is suggested to be useful in hypertension. Under in vitro conditions, it activates vanilloid TRPV1 and inhibits serotonin 5-HT3 receptors, i.e., receptors involved in the Bezold-Jarisch reflex stimulation. The aim of our study was to compare the cardiovascular effects of CBD in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto…

Frontiers in Pharmacology PubMed Central Open Access

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