Readable research linked to original sources
Articles
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
5 articles
Newest firstBackground Central and peripheral inflammation are under intense investigation because of their increasing relationship with neuropsychiatric disorders and neurodegeneration. Microglia, the main component of the innate immune system within the brain, coordinate neuroinflammatory processes, so they are a major focus of attention. Recent research has highlighted the capacity of microglia to acquire immunological mem…
Open article record in new tab ↗Background and objectives Knowledge about the effects of medications and supplements on orthodontic tooth movement (OTM) is imperative for orthodontists. This study aimed to assess the effects of acute and chronic stress and cannabinoid extract (CE; marijuana) injection on OTM in rats. Materials and methods In this animal experimental study, 220 male Wistar rats were randomly assigned to 22 subgroups (n = 10) in t…
Open article record in new tab ↗Background Recent research indicates that both endocannabinoids (eCB) and heart rate variability (HRV) are associated with stress-induced experiences. However, these underlying mechanisms are not elucidated. The present study aims to investigate whether exposure to acute and chronic stress conditions can give rise to measurable changes, both to the peripheral eCB ligands and HRV. Methods Thirteen candidates under…
Anxiety disorder is a well-recognized condition observed in subjects submitted to acute stress. Although the brain mechanisms underlying this disorder remain unclear, the available evidence indicates that oxidative stress and GABAergic dysfunction mediate the generation of stress-induced anxiety. Cannabinoids are known to be efficient modulators of behavior, given that the activation of the cannabinoid receptors t…
Background Long-term exposure to stress has been demonstrated to cause neuroinflammation through a sustained overproduction of free radicals, including nitric oxide, via an increased inducible nitric oxide synthase activity. We previously demonstrated that inducible nitric oxide synthase activity and mRNA are significantly upregulated in the rat hippocampus following just 4 hours of restraint stress. Similar to ni…