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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
11 articles
Newest firstBacteremia is a major contributor to global morbidity and mortality, particularly in low- and middle-income countries where diagnostic delays and empirical antimicrobial misuse exacerbate resistance. This study assessed the accuracy of OneChoice(R), an artificial intelligence (AI)-based Clinical Decision Support System (CDSS), in guiding antimicrobial therapy for bloodstream infections (BSIs) in Lima, Peru. A retr…
Open article record in new tab ↗The COVID-19 pandemic exposed vulnerabilities in health systems abilities to detect, report, and respond to threats. Inadequate preparedness led to healthcare worker infections (HCW), essential service disruptions, and impacts on communities. Primary health care (PHC) is often overlooked in health security initiatives. Epidemic Ready Primary Health Care (ERPHC) is an initiative that strengthens PHC facilities to p…
Open article record in new tab ↗BackgroundThe potential of generative artificial intelligence (GenAI) to augment clinical consultation services in clinical microbiology and infectious diseases (ID) is being evaluated. MethodsThis cross-sectional study evaluated the performance of four GenAI chatbots (GPT-4.0, a Custom Chatbot based on GPT-4.0, Gemini Pro, and Claude 2) by analysing 40 unique clinical scenarios synthesised from real-life clinical…
PurposeThe prospective Viral load Cohort North-East Lesotho (VICONEL) aims to support clinical management and generate scientific evidence to inform HIV care. Specifically, VICONEL allows for monitoring of HIV treatment outcomes and health system performance, encompasses a biobank for further research with routinely collected blood plasma samples of consenting participants, and provides a valuable framework for ne…
Open article record in new tab ↗BackgroundGenerative artificial intelligence (AI) technology has the revolutionary potentials to augment clinical practice and telemedicine. The nuances of real-life patient scenarios and complex clinical environments demand a rigorous, evidence-based approach to ensure safe and effective application. MethodsWe present a protocol for the systematic evaluation of generative AI large language models (LLMs) as chatbo…
Open article record in new tab ↗Human immunodeficiency virus (HIV) infection is associated with a chronic inflammatory stage and continuous activation of inflammasome pathway. We studied the anti-inflammatory effects of the compound cannabidiol (CBD) in comparison with Δ (9)-tetrahydrocannabinol [Δ(9)-THC] in human microglial cells (HC69.5) infected with HIV. Our results showed that CBD reduced the production of various inflammatory cytokines an…
BackgroundCOVID-19 has tormented the global health and economy like no other event in the recent past. Researchers and policymakers have been working strenuously to end the pandemic completely. Methodology/Principal FindingsInfectious disease dynamics could be well-explained at an individual level with established contact networks and disease models that represent the behaviour of the infection. Hence, an Agent-Ba…
Open article record in new tab ↗The use of marijuana is highly prevalent among young men who have sex with men (YMSM). Past work has also shown that inflammation is elevated among YMSM, independent of HIV status. Here, we aim to examine the relationship between marijuana use and inflammation among this high-risk cohort, relative to use of other substances. Data were collected among YMSM aged 16-29 in Chicago. Multiplex cytokine and inflammatory…
Open article record in new tab ↗The healthcare industry is in dire need for rapid microbial identification techniques. Microbial infection is a major healthcare issue with significant prevalence and mortality, which can be treated effectively during the early stages using appropriate antibiotics. However, determining the appropriate antibiotics for the treatment of the early stages of infection remains a challenge, mainly due to the lack of rapi…
The Cannabis plant contains numerous components, including cannabinoids and other active molecules. The phyto-cannabinoid activity is mediated by the endocannabinoid system. Cannabinoids affect the nervous system and play significant roles in the regulation of the immune system. While Cannabis is not yet registered as a drug, the potential of cannabinoid-based medicines for the treatment of various conditions has…
Open article record in new tab ↗BackgroundCOVID-19, the disease associated with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is currently a global pandemic with several thousands of confirmed cases of infection and death. However, the death rate across affected countries shows variation deserving of critical evaluation. MethodsIn this study, we evaluated differentials in COVID-19 confirmed cases of infection and associated de…