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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
37 articles
Newest firstNeisseria gonorrhoeae, the causative agent of the second-most prevalent sexually transmitted bacterial disease globally, has been classified as an urgent threat to public health and a high-priority pathogen. Concerningly, N. gonorrhoeae has developed resistance to nearly all FDA-approved drugs. Currently, no approved oral therapies exist, with parenteral administration of ceftriaxone as the only available FDA-appr…
Open article record in new tab ↗BackgroundAntimicrobial resistance (AMR) is a major public health threat globally, with a disproportionate burden in sub-Saharan Africa. Faith-based health facilities provide essential healthcare services to underserved populations, yet data on antimicrobial use in these settings remain limited. AimTo assess antimicrobial use in Christian Health Association of Malawi health facilities using the World Health Organi…
BackgroundRising antibiotic resistance challenges empirical therapies for urinary tract infections (UTIs). This study evaluated the microbial etiology, susceptibility profiles, and multidrug resistance (MDR) patterns of uropathogens among outpatients at the Berekum Holy Family Hospital, Ghana. MethodsThis cross-sectional study (February-August 2021) screened 263 symptomatic outpatients. Mid-stream urine samples un…
Methicillin-resistant Staphylococcus (MRS) infections are a significant public health concern. Anterior nares serve as a major reservoir and source of spread of MRS ssp. People living with HIV (PLWHIV) tend to be at higher risk of colonisation with MRS organisms due to frequent healthcare exposure. We assessed the prevalence of MRS nasal carriage and associated factors among PLWHIV at the HIV clinic of Kiruddu Nat…
The inappropriate use of antimicrobials enhances antimicrobial resistance (AMR). Antimicrobial stewardship (AMS) is a coordinated effort of prescribers, pharmacists, and nurses. Still, local data regarding AMS-related knowledge, attitudes, and practices (KAP) are scarce in many low and middle-income countries. We evaluated KAP regarding AMS among the healthcare providers at Komfo Anokye Teaching Hospital (KATH), G…
BackgroundIncreasing Watch-group antibiotic use may be contributing to antimicrobial resistance burden in sub-Saharan Africa. We evaluated the effect of a community-based, co-created intervention bundle targeting all community-level healthcare providers and communities they serve, on Watch-group antibiotic use and patient management. MethodsIn a cluster-randomised, controlled trial in Burkina Faso (BF) and Democra…
BackgroundAntimicrobial resistance (AMR) is a growing global health concern driven largely by inappropriate antimicrobial use. Antimicrobial stewardship programs (ASPs), guided by the Centers for Disease Control and Prevention (CDC) core elements, are essential for optimizing antimicrobial use. However, adherence to these practices and the barriers faced by healthcare workers remain inadequately explored, particul…
Open article record in new tab ↗From 2021 to 2025, MRSA emerged as a major multidrug-resistant pathogen in the study area. Among 545 S. aureus isolates, 67.2% were MRSA, disproportionately affecting children under five (26.5%) and males (55.5%). Case incidence more than doubled by 2025, suggesting rising transmission or resistance. Most isolates were hospital-associated (85.2%), predominantly from outpatients (88.5%), with middle ear discharge a…
Open article record in new tab ↗In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. The bioinformatic analysis allowed us to determine the spatial architecture of MLE-15, whose components were bactericidal peptide cecropin A connected via a flexible linker to the cell wall binding domain (CBD) of mesophilic 201ϕ2 - 1 endolysin and ca…
Background and aim Canine pyoderma is a common dermatological condition, often caused by Staphylococcus pseudintermedius and related methicillin-resistant strains (MRSP and MRSS). Rising antimicrobial resistance necessitates alternative topical therapies. This study comparatively evaluated the in vitro antibacterial activity of P. betel leaf extract (both solvent-based and nanoemulsion forms) and cannabidiol (CBD)…
BackgroundUrinary tract infections (UTIs) remain a common clinical condition requiring antibiotic prescription among adult outpatients in low- and middle-income countries (LMICs). Data regarding the prevalence, patterns of bacteria and their antibacterial susceptibility profile for community acquired UTI are limited. MethodsA hospital-based cross-sectional study was conducted from May to August 2024 at Igoma and B…
BackgroundKlebsiella pneumoniae is a major pathogen causing both healthcare- and community-associated infections. Traditionally classified as classical (cKp) or hypervirulent (hvKp), recent reports suggest increasing overlap between antimicrobial resistance (AMR) and virulence, leading to "dual-risk" clones that are both invasive and difficult to treat. ObjectivesTo perform a large-scale genomic analysis of K. pne…
Open article record in new tab ↗BackgroundHospital-acquired infections (HAIs) remain a global public-health concern, particularly in low- and middle-income countries where infection-prevention resources are limited. Surgical-site infections (SSIs) and urinary-tract infections (UTIs) are among the most frequent HAIs and contribute to increased morbidity and healthcare costs. Genomic surveillance provides insights into the diversity, antimicrobial…
Open article record in new tab ↗ObjectivesTo characterize carbapenem-resistant Acinetobacter baumannii isolates associated with healthcare-associated infections (HAIs) in Colombia using whole-genome sequencing (WGS). MethodsA total of 83 A. baumannii isolates collected between 2012 and 2015 were sequenced using the Illumina platform. Raw reads were assembled by SPAdes and classified via multilocus sequence typing (MLST), using the Pasteur, Oxfor…
Open article record in new tab ↗Bacteremia is a major contributor to global morbidity and mortality, particularly in low- and middle-income countries where diagnostic delays and empirical antimicrobial misuse exacerbate resistance. This study assessed the accuracy of OneChoice(R), an artificial intelligence (AI)-based Clinical Decision Support System (CDSS), in guiding antimicrobial therapy for bloodstream infections (BSIs) in Lima, Peru. A retr…
This article reports an unusual Klebsiella pneumoniae clinical isolate, KpMVR1, resistant to meropenem-vaborbactam, imipenem-relebactam, and ceftazidime-avibactam, and investigates the underlying genetic alterations using comparative genomics and molecular experiments. Resistance to carbapenems and third-generation cephalosporins is increasing in K. pneumoniae globally, restricting therapeutic options. The {beta}-…
Drug-resistant infections with extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) are increasingly problematic, especially in healthcare settings. ESBL-E infections lead to a worse treatment outcome and often require escalating antibiotic treatment to reserve antibiotics such as carbapenems. Understanding how these bacteria are transmitted within healthcare settings is complex and not well unders…
Sepsis (blood stream infection) caused by multidrug-resistant (MDR) bacteria, particularly Escherichia coli, represents a significant global health threat due to high morbidity, mortality, and limited treatment options. E. coli, a major causative agent of bloodstream infections, has evolved highly virulent and MDR strains, which contribute to the increasing burden of antimicrobial resistance (AMR), complicating cl…
Klebsiella pneumoniae is a frequent cause of antimicrobial resistant healthcare associated infections in neonates across sub-Saharan Africa, with multiple lineages associated with neonatal sepsis. However, the full diversity of circulating strains and key reservoirs facilitating transmission within hospitals is unknown. We investigated the population structure and within- sample diversity of K. pneumoniae in a Mal…
Antimicrobial resistance, a significant and escalating public health threat, has extended its reach beyond healthcare settings to diverse environments such as urban beaches, wastewater plants, and household pets. A recent study even found bacteria in permafrost with genes encoding beta-lactamases, enzymes that confer resistance to beta-lactam antibiotics. Our previous study identified 2340 potential beta-lactamase…
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