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Research Article 2025CC BYFree full text

Metabolism of Cannabidiol in Respiratory-Associated Cells and HepG2-Derived Cells and Molecular Docking of Cannabidiol and Its Metabolites with CYP Enzymes and Cannabinoid Receptors.

Krittawan Tongkanarak, Pijush Kumar Paul, Muhammad A Khumaini Mudhar Bintang, Roongnapa Suedee, Somchai Sawatdee, Teerapol Srichana +1 more

Cannabidiol (CBD) has been reported in medical applications for various indications. The enzymatic metabolism of CBD is not fully understood in the different routes of administration. This research aimed to identify the CBD metabolites after incubation of CBD with derived hepatocyte cells (HepG2), bronchial epithelial cells (NCI-H358), alveolar cells (A549), and alveolar macrophage cells (NR8383). A liquid chromat…

International Journal of Molecular Sciences Europe PMC

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Research Article 2020CC BY-NCFree full text · non-commercial reuse

Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135).

Sabrina Jones, Azure L. Yarbrough, William E. Fantegrossi, Paul L. Prather, John M. Bush, Anna Radominska‐Pandya +1 more

Synthetic cannabinoids (SCBs), designer drugs marketed as legal alternatives to marijuana, act as ligands to cannabinoid receptors; however, they have increased binding affinity and potency, resulting in toxicity symptoms such as cardiovascular incidents, seizures, and potentially death. N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (STS-135) is a third generation SCB. When incubated with hepatocyt…

Pharmacology Research & Perspectives