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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
5 articles
Newest firstThe Convention on Biological Diversity (CBD) emphasises the role of biodiversity in delivering benefits essential for all people and, as a result, seeks to safeguard all life-forms. The indices that are used to measure progress towards international conservation and sustainability goals, however, focus solely on the 'native' component of biodiversity. A subset of non-native species can cause undesirable economic,…
Open article record in new tab ↗Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. For this reason, there is a tremendous medical interest in harnessing the beneficial effects of THC. Behavioral studies carried out in mice lacking 5-HT2A receptors…
Open article record in new tab ↗For over 50 years, many medical drugs have been effectively banned from research and clinical treatment in the vain hope that this will stop recreational use. The scientific community should now challenge this pointless ban and get governments to improve their regulations so science can flourish. The United Nations drug control conventions of 1960 and 1971 and later additions have inadvertently resulted in perhaps…
Open article record in new tab ↗Protein Kinase A (PKA) is the major receptor for the cyclic adenosine monophosphate (cAMP) secondary messenger in eukaryotes. cAMP binds to two tandem cAMP-binding domains (CBD-A and -B) within the regulatory subunit of PKA (R), unleashing the activity of the catalytic subunit (C). While CBD-A in RIα is required for PKA inhibition and activation, CBD-B functions as a "gatekeeper" domain that modulates the control…
How can we harness the beneficial effects of cannabis on pain without the harmful effects on memory? A new study shows that the harmful effects are specifically mediated by a partnership between cannabinoid and serotonin receptors, with pharmaceutical implications.
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