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Research Article 2024CC BYFree full text

Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.

Keita Sakurai, Aya M. Tokumaru, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori +44 more

Purpose Due to the indistinguishable clinical features of corticobasal syndrome (CBS), the antemortem differentiation between corticobasal degeneration (CBD) and its mimics remains challenging. However, the utility of conventional magnetic resonance imaging (MRI) for the diagnosis of CBD has not been sufficiently evaluated. This study aimed to investigate the diagnostic performance of conventional MRI findings in…

Neuroradiology Europe PMC

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Research Article 2019CC BYFree full text

Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies.

Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwata

The mechanism of neuronal dysfunction via tau aggregation in tauopathy patients is controversial. In Alzheimer's disease (AD), we previously reported mislocalization of the DNA repair nuclear protein BRCA1, its coaggregation with tau, and the possible importance of the subsequent DNA repair dysfunction. However, whether this dysfunction in BRCA1 also occurs in other tauopathies is unknown. The aim of this study wa…

Brain Sciences Europe PMC

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