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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
2 articles
Newest firstThe matrix effect limits the accuracy of quantitation of the otherwise popular metabolomics technique liquid chromatography coupled to mass spectrometry (LC-MS). The gold standard to correct for this phenomenon, whereby compounds coeluting with the analyte of interest cause ionization enhancement or suppression, is to quantify an analyte based on the peak area ratio with an isotopologue added to the sample as an i…
Open article record in new tab ↗BackgroundRisk prediction models are used in healthcare settings to tailor therapies to individuals most likely to benefit. Despite appropriate external validation, difference in local characteristics (e.g. patient mix) may attenuate model performance. Prior to any implementation it is therefore advisable to explore local performance, typically requiring a modest amount of historic data. Depending on model perform…