CANNABISHUB: Medical Cannabis Research Engine

Research Article 2023CC BY-NCFree full text · non-commercial reuse

Examining the Systemic Bioavailability of Cannabidiol and Tetrahydrocannabinol from a Novel Transdermal Delivery System in Healthy Adults: A Single-Arm, Open-Label, Exploratory Study.

Gyula Varadi, Zhen Zhu, Henry D Crowley, Marc Moulin, Rajib Dey, Erin D Lewis +1 more

Introduction Transdermal cannabinoids may provide better safety and bioavailability profiles compared with other routes of administration. This single-arm, open-label study investigated a novel topical transdermal delivery system on the pharmacokinetics of cannabidiol (CBD) and tetrahydrocannabinol (THC). Methods Participants were 39.5 ± 7.37 years old and healthy, based on a review by the Medical Director. Blood…

Advances in Therapy Europe PMC

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Research Article 2022CC BY-NCFree full text · non-commercial reuse

Use of a Novel EEG-Based Objective Test, the Cognalyzer®, in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework.

Dan Bosnyak, Alison C. McDonald, Israel Gasperin Haaz, Weikai Qi, David C. Crowley, Najla Guthrie +1 more

Introduction Current methods to detect recent delta-9-tetrahydrocannabinol (THC) use cannot objectively quantify its psychoactive effects (PE). The Cognalyzer®, an electroencephalography (EEG)-based method, detects and quantifies the strength of THC-induced PE on a scale from 0 to 100%. This study assesses the relationship between the magnitude of Cognalyzer® PE predictions and reported subjective drug effects for…

Neurology and Therapy

Research Article 2022CC BYFree full text

A Randomized, Triple-Blind, Comparator-Controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Cannabis Use History.

Volker Berl, Yasmin L. Hurd, Bruce H. Lipshutz, Markus Roggen, Eric J. Mathur, Malkanthi Evans

Background: An oral route of administration for tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) eliminates the harmful effects of smoking and has potential for efficacious cannabis delivery for therapeutic and recreational applications. We investigated the pharmacokinetics of CBD, Δ9-THC, 11-OH-THC, and 11-nor-9-carboxy-Δ9-THC (THC-COOH) in a novel oral delivery system, Solutech™, compared to medium-chain trig…

Cannabis and Cannabinoid Research

Research Article 2021CC BY-NCFree full text · non-commercial reuse

Sensitivity, Specificity and Accuracy of a Novel EEG-Based Objective Test, the Cognalyzer®, in Detecting Cannabis Psychoactive Effects.

Alison C McDonald, Israel Gasperin Haaz, Weikai Qi, David C Crowley, Najla Guthrie, Malkanthi Evans +1 more

Introduction Current standards for identifying recent cannabis use are based on body fluid testing. The Cognalyzer® is a novel electroencephalography (EEG) measurement device and algorithm designed to objectively characterize brainwave alterations associated with cannabis. The objective of this study was to assess the accuracy, sensitivity and specificity levels of the Cognalyzer® to characterize brainwave alterat…