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Research Article 2025CC BY-NCFree full text · non-commercial reuse

Cannabidiol as a Neuroprotective Agent in Acrylamide-Induced Neurotoxicity: Effects on Oxidative Stress, Inflammation, and Cholinergic Function in Male Mice.

Korina Atsopardi, Konstantinos Mesiakaris, Ioannis Sotiropoulos, Marigoula Margarity, Konstantinos Poulas

The neuroprotective potential of cannabidiol (CBD) was assessed in a mouse model of acrylamide-induced neurotoxicity. Acrylamide (AA), an environmental and dietary pollutant, is known to cross the blood-brain barrier and induce oxidative stress, inflammation and neurotoxic effects. Male C57BL/6 mice were randomly assigned to four groups: Control (Con), Acrylamide (AA), Cannabidiol (CBD), and a combination treatmen…

Journal of Neuroscience Research Europe PMC

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Research Article 2021-04-20CC BYFree full text

Cannabidiol pretreatment attenuates locomotor alterations and cytokine production in an autoimmune hepatitis model

Konstantinos Mesiakaris, Korina Atsopardi, Marigoula Margarity, Konstantinos Poulas

Cannabidiol (CBD) is a major active component of the Cannabis plant ( Cannabis Sativa L .), which unlike tetrahydrocannabinol (THC) is devoid of euphoria-inducing properties. Broadly, CBD has demonstrated anxiolytic-like, anti-inflammatory and immunomodulatory effects. Concanavalin A (ConA) is a lectin found in the jack bean ( Canavalia ensiformis ) and it has been associated with a variety of toxicological effect…

bioRxiv bioRxiv

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