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Research Article 2026CC BY-NCFree full text · non-commercial reuse

Age and Gender Heterogeneity in Adverse Drug Reactions Associated with Hemp Use: Evidence from the FDA Pharmacovigilance Data in the Last Two Decades.

Chengwen Teng, Jun Wu, Jing Yuan, Z Kevin Lu

Background Hemp-derived products are increasingly used for medical and wellness purposes following legalization, yet systematic safety data remain limited. Objective We aimed to identify the most common adverse drug reactions associated with hemp use and to evaluate age- and gender-specific differences in risk. Methods We analyzed adverse event reports submitted to the US Food and Drug Administration Adverse Event…

Drugs - Real World Outcomes Europe PMC

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Research Article 2021CC BYFree full text

Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia.

Jun Wu, Nu Chen, Yongqing Liu, Grzegorz Godlewski, Henry J Kaplan, Sarah H Shrader +3 more

Cannabidiol (CBD) exhibits anti-inflammatory and neuroprotective properties and is suggested to be effective in the pre-clinical and clinical treatment of illnesses of the central nervous system (CNS). Two major types of CNS glial cells, astrocytes and microglia, play critical roles in the development and pathogenesis of CNS diseases. However, the mechanisms by which CBD plays an anti-inflammatory and neuroprotect…

PLoS ONE Europe PMC

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Research Article 2018CC BYFree full text

LH-21, A Peripheral Cannabinoid Receptor 1 Antagonist, Exerts Favorable Metabolic Modulation Including Antihypertensive Effect in KKAy Mice by Regulating Inflammatory Cytokines and Adipokines on Adipose Tissue.

Ziqi Dong, Hui Gong, Yadan Chen, Hong Wu, Jun Wu, Yinghong Deng +1 more

Patients with obesity are susceptible to hypertension and diabetes. Over-activation of cannabinoid receptor 1 (CB1R) in adipose tissue is proposed in the pathophysiology of metabolic disorders, which led to the metabolic dysfunction of adipose tissue and deregulated production and secretion of adipokines. In the current study, we determined the impact of LH-21, a representative peripheral CB1R antagonist, on the o…

Frontiers in Endocrinology Europe PMC

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Age and Gender Heterogeneity in Adverse Drug Reactions Associated with Hemp Use: Evidence from the FDA Pharmacovigilance Data in the Last Two Decades.

Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia.

LH-21, A Peripheral Cannabinoid Receptor 1 Antagonist, Exerts Favorable Metabolic Modulation Including Antihypertensive Effect in KKAy Mice by Regulating Inflammatory Cytokines and Adipokines on Adipose Tissue.