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19172026

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Author: John L Robinson

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Research Article 2019CC0CC0 allows this article to remain publicly readable here. Any reuse must still follow the recorded source terms.Free full text

Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau).

Garrett S Gibbons, Soo-Jung Kim, John L Robinson, Lakshmi Changolkar, David J Irwin, Leslie M Shaw +2 more

Pathological tau aggregates in Alzheimer's disease (AD) and frontotemporal lobar degeneration-tau (FTLD-tau) adopt distinct conformations differentiated by the AD-tau specific monoclonal antibody (mAb) GT-38 that are not readily visualized using phosphorylation-specific anti-tau mAbs. To determine the extent of co-morbid AD-tau pathology in FTLD-tau, we performed immunohistochemical (IHC) staining with GT-38 and a…

Acta Neuropathologica Communications Europe PMC↗

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