Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
6 articles
Newest firstBackground and aims E-cigarettes can aid smoking cessation and reduce carcinogen exposure. Understanding differences in characteristics between young adults who quit smoking, with or without e-cigarettes, or dual use can help tailor interventions. The aim of this study was to describe first transitions from smoking and explore substance use, sociodemographic, and health characteristic associations with the probabi…
Open article record in new tab ↗BackgroundParental smoking increases offspring smoking risk. Young people with mental health difficulties are more likely to have parents who smoke and start smoking themselves. Improving mental health in youth could help disrupt intergenerational cycles of nicotine use, but the extent to which depressive symptoms mediate the link between parental and offspring smoking remains unclear. MethodsWe used data on 6,729…
Open article record in new tab ↗BackgroundCannabis and tobacco use are consistently associated with major depressive disorder (MDD) in conventional observational studies. However, these substances are often co-used, and the independent causal role of cannabis use in risk of MDD remains unclear. MethodsUnivariable and multivariable MR (MVMR) were used to explore the total and independent causal effects of genetic liability to tobacco use and cann…
Open article record in new tab ↗ImportanceTraditional observational epidemiological studies have consistently found an association between tobacco use, cannabis use and subsequent mental ill-health. However, the extent to which this association reflects an increased risk of new-onset mental ill-health is unclear and may be biased by unmeasured confounding. ObjectiveTo examine the association between cannabis use, tobacco use and risk of incident…
Open article record in new tab ↗Knowledge of the impact of smoking on healthcare costs is important for establishing the external effects of smoking and for evaluating policies intended to modify this behavior. Conventional analysis of this association is difficult because of omitted variable bias, reverse causality, and measurement error. We approached these challenges using a Mendelian Randomization study design, in which genetic variants asso…
Open article record in new tab ↗Attention-deficit hyperactivity disorder (ADHD) has consistently been associated with substance use, but the nature of this association is not fully understood. To inform intervention development and public health messages, a vital question is whether there are causal pathways from ADHD to substance use and/or vice versa. We applied bidirectional Mendelian randomization, using summary-level data from the largest a…
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