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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
2 articles
Newest firstABSTRACT Background Synthetic Cannabinoids Receptor Agonists (SCRAs) are the largest group of new psychoactive substances monitored worldwide. 5F-MDMB-PICA is a recent SCRA classified as a potent full agonist at CB1/CB2 receptors able to activate the mesolimbic dopamine (DA) transmission in adolescent but not in adult mice. Here, we have studied its reinforcing effects in adolescent mice and characterized the neur…
Open article record in new tab ↗2-Arachidonoylglycerol (2-AG) is the most potent endogenous ligand of brain cannabinoid CB1 receptors and is synthesized on demand from 2-arachidonate-containing phosphoinositides by the action of diacylglycerol lipase in response to increased intracellular calcium. Several studies indicate that the endocannabinoid (eCB) system is involved in the mechanism of reward and that diverse drugs of abuse increase brain e…