Readable research linked to original sources
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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
12 articles
Newest firstObjectivesTo evaluate temporal changes in the incidence and prevalence of 19 long-term conditions in England, quantifying the impact of the COVID-19 pandemic on diagnosis rates by disease, age group, sex, socioeconomic status, and ethnicity. DesignObservational cohort study. SettingPrimary care and hospital admission data, with the approval of NHS England. Participants27,132,190 individuals registered with general…
Open article record in new tab ↗ObjectivesWe aimed to estimate how rheumatology healthcare use has changed since the COVID-19 pandemic and determine demographic characteristics associated with observed changes in healthcare use. MethodsUsing three primary and secondary care electronic health record datasets in England (with the approval of NHS England), Scotland, and Wales, we identified individuals with a diagnosis of rheumatoid arthritis (RA)…
Open article record in new tab ↗ObjectivesTo examine the impact of the pandemic on deprivation-related inequalities in hospitalisations for CVD conditions in Denmark and England between March 2018 and December 2021. DesignA series of monthly cross-sectional studies separately in England and Denmark. Setting: With the approval of NHS England, we used English primary care electronic health records, linked to secondary care and death registry data…
Open article record in new tab ↗BackgroundThe COVID-19 pandemic disrupted healthcare delivery, including difficulty accessing in-person care, which may have increased the need for strong pharmacological pain relief. MethodsWith NHS England approval, we used routine clinical data from >20 million general practice adult patients in OpenSAFELY-TPP. Using interrupted time series analysis, we quantified prevalent and new opioid prescribing prior to t…
Open article record in new tab ↗BackgroundHealthcare across all sectors, in the UK and globally, was negatively affected by the COVID-19 pandemic. We analysed healthcare services delivered to people with pancreatic cancer from January 2015 to March 2023 to investigate the effect of the COVID-19 pandemic. MethodsWith the approval of NHS England, and drawing from a nationally representative OpenSAFELY-TPP dataset of 24 million patients (over 40% o…
Open article record in new tab ↗BackgroundThe COVID-19 pandemic created unprecedented pressure on healthcare services. This study aimed to investigate if disease-modifying anti-rheumatic drug (DMARD) safety monitoring was affected during the COVID-19 pandemic. MethodsA population-based cohort study was conducted with the approval of NHS England, using the OpenSAFELY platform to access electronic health record data from 24{middle dot}2 million pa…
BackgroundThe COVID-19 pandemic and associated national lockdowns created unprecedented disruption to healthcare, with reduced access to services and planned clinical encounters postponed or cancelled. It was widely anticipated that failure to obtain timely treatment would cause progression of illness and increased hospital admissions. Additional concerns were that social and spatial inequalities would widen given…
Open article record in new tab ↗BackgroundThe COVID-19 pandemic has disrupted healthcare activity across a broad range of clinical services. The NHS stopped non-urgent work in March 2020, later recommending services be restored to near-normal levels before winter where possible. AimsUsing routinely collected data, our aim was to describe changes in the volume and variation of coded clinical activity in general practice in: (i) cardiovascular dis…
Open article record in new tab ↗ObjectivesTo compare the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and the ChAdOx1 (Oxford-AstraZeneca) COVID-19 vaccines against infection and COVID-19 disease in health and social care workers. DesignCohort study, emulating a comparative effectiveness trial. SettingLinked primary care, hospital, and COVID-19 surveillance records available within the OpenSAFELY-TPP research platform. Participants317,34…
Open article record in new tab ↗BackgroundThere is concern about medium to long-term adverse outcomes following acute COVID-19, but little relevant evidence exists. We aimed to investigate whether risks of hospital admission and death, overall and by specific cause, are raised following discharge from a COVID-19 hospitalisation. Methods and FindingsWorking on behalf of NHS-England, we used linked primary care and hospital data in OpenSAFELY to c…
Open article record in new tab ↗BackgroundThe COVID-19 pandemic has disrupted healthcare activity globally. The NHS in England stopped most non-urgent work by March 2020, but later recommended that services should be restored to near-normal levels before winter where possible. The authors are developing the OpenSAFELY NHS Service Restoration Observatory, using data to describe changes in service activity during COVID-19, and reviewing signals fo…
Open article record in new tab ↗BackgroundClose contact with children may provide cross-reactive immunity to SARs-CoV-2 due to more frequent prior coryzal infections from seasonal coronaviruses. Alternatively, close contact with children may increase risk of SARs-CoV-2 infection. We investigated whether risk of infection with SARs-CoV-2 and severe outcomes differed between adults living with and without children. MethodsWorking on behalf of NHS…
Open article record in new tab ↗