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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
Loading articles data…
Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
5 articles
Newest firstJails have been hypothesized to be hotspots for the spread of methicillin-resistant Staphylococcus aureus (MRSA). We integrate genomic and epidemiologic data to investigate USA300 MRSA transmission in an urban jail and its connected communities. A genome-wide association study of 308 jail isolates from 2015-2018 revealed a plasmid encoding the ermC clindamycin/erythromycin resistance gene was associated with a 6-f…
Open article record in new tab ↗Carbapenem-resistant Klebsiella pneumoniae (CRKP) is recognized as an urgent public health threat due to its multidrug resistance and ability to spread rapidly in healthcare facilities. The frequent movement of colonized and infected patients between different facilities makes it challenging to discern where individual patients acquire CRKP, and in turn, identify facilities making the greatest contributions to reg…
Open article record in new tab ↗BackgroundCarbapenem-resistant Enterobacterales (CRE) are among the most concerning antibiotic resistance threats due to high rates of multidrug resistance, transmissibility in healthcare settings, and high mortality rates. We evaluated the potential for regional genomic surveillance to track blaKPC-carrying CRE (KPC-CRE) transmission across healthcare facilities in three U.S. states. MethodsClinical isolates were…
Open article record in new tab ↗There is an urgent need to improve our understanding of how new antibiotic resistant organisms emerge and spread. A high-priority resistance threat is the ST258 lineage of carbapenem-resistant Klebsiella pneumoniae. Here, we studied resistance to the last-line drug colistin among ST258 by tracking its evolution across 21 U.S. hospitals over the course of a year. Phylogenetic analysis supported a significant fitnes…
BackgroundCarbapenem-resistant Enterobacterales (CRE) harboring blaKPC have been endemic in Chicago-area healthcare networks for more than a decade. During 2016-2019, a series of regional point prevalence surveys identified increasing prevalence of blaNDM-containing CRE in multiple long-term acute care hospitals (LTACHs) and ventilator-capable skilled nursing facilities (vSNFs). We performed a genomic epidemiology…
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