Application of Monoclonal Antibodies against Naturally Occurring Bioactive Ingredients
Abstract Monoclonal antibodies (Mabs) are widely used in a variety of fields, including protein identification, life sciences, medicine, and natural…
Review Article
Receptors and Signaling Pathways Controlling Beta-Cell Function and Survival as Targets for Anti-Diabetic Therapeutic Strategies
Abstract Preserving the function and survival of pancreatic beta-cells, in order to achieve long-term glycemic control and prevent complications, is…
Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury
Abstract Brain edema is a critical complication arising from stroke and traumatic brain injury (TBI) with an important impact on…
DNA Methylation in Autism Spectrum Disorders: Biomarker or Pharmacological Target?
Abstract Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disabilities with persistent impairments in cognition, communication, and social…
Pharmacological Treatment of Fibromyalgia Syndrome: A Practice-Based Review
Abstract Purpose of Review: Fibromyalgia Syndrome (FMS) is a complex chronic pain condition characterized by widespread musculoskeletal pain and numerous…
Cannabis therapy in rheumatological diseases: A systematic review
Abstract Cannabis has been used in rheumatic diseases as therapy for chronic pain or inflammatory conditions. Herein, the authors systematically…
Natural Product-Inspired Dopamine Receptor Ligands
Abstract Due to their evolutionary bias as ligands for biologically relevant drug targets, natural products offer a unique opportunity as…
The Effect of Phytocannabinoids and Endocannabinoids on Nrf2 Activity in the Central Nervous System and Periphery
Abstract The relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) and phytocannabinoids/endocannabinoids (pCBs/eCBs) has been investigated in a variety…
The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update
Abstract The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia…
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities
Abstract Depression is the fourth most serious disease in the world. Left untreated, it is a cause of suicide attempts,…