The Role of Tau in Neuronal Function and Neurodegeneration
Abstract Tau protein plays a pivotal role in maintaining neuronal structure and function through its regulation of microtubule stability and…
tauopathies
Correcting tau isoform ratios with a long-acting antisense oligonucleotide alleviates 4R-tauopathy phenotypes
Abstract Tau, a microtubule-binding protein linked to tauopathies like Alzheimer’s disease and frontotemporal lobar degeneration (FTLD), has 3-repeat (3R) and…
Seeding activity of skin misfolded tau as a biomarker for tauopathies
Abstract Background: Tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically hyperphosphorylated tau protein in…
Cerebrospinal Fluid Total and Phosphorylated Tau Protein in Behavioral Variant Frontotemporal Dementia, Progressive Supranuclear Palsy, Corticobasal Syndrome and Non-Fluent Agrammatic Primary Progressive Aphasia: A Systematic Review and Meta-Analysis
Abstract (1) Background: Frontotemporal lobar degeneration (FTLD) is a generic term which refers to multiple pathologies, including FTLD-tau. The most…
Tau protein profiling in tauopathies: a human brain study
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s13024-024-00741-9. Article type: Research Article Keywords: Tau, Tauopathies, Mass…
Neuropathological changes associated with aberrant cerebrospinal fluid p-tau181 and Aβ42 in Alzheimer’s disease and other neurodegenerative diseases
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-024-01758-3. Article type: Research Article Keywords: Cerebrospinal fluid, Biomarkers,…
Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights
Abstract Previous studies have suggested a relationship between the number of CAG triplet repeats in the HTT gene and neurodegenerative…
Neuroimmune proteins can differentiate between tauopathies
Abstract Background: Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The…
Structural mapping techniques distinguish the surfaces of fibrillar 1N3R and 1N4R human tau
Abstract The rigid core of intracellular tau filaments from Alzheimer’s disease (AD), Pick’s disease (PiD), and Corticobasal disease (CBD) brains…
Association of CD2AP neuronal deposits with Braak neurofibrillary stage in Alzheimer’s disease
Abstract Genome‐wide association studies have described several genes as genetic susceptibility loci for Alzheimer’s disease (AD). Among them, CD2AP encodes…