The Significance of Vascular Pathogenesis in the Examination of Corticobasal Syndrome
Abstract Corticobasal syndrome (CBS) is a clinical entity, classified as an atypical Parkinsonism, characterized by both motor and higher cortical…
tauopathies
Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers
Abstract Supplementary Information: The online version of this article (10.1186/s40478-021-01119-4) contains supplementary material, which is available to authorized users. Article…
Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies
Abstract We recently identified Secernin-1 (SCRN1) as a novel amyloid plaque associated protein using localized proteomics. Immunohistochemistry studies confirmed that…
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies
Abstract Background: The innate immune system is known to be involved early in the pathogenesis of Alzheimer’s disease (AD) and…
Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options
Abstract There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological…