Enhancement of fiber content and cannabinoids of hemp using arbuscular mycorrhizal fungi and endophytic fungi
Abstract This study aimed to investigate the efficiency of arbuscular mycorrhizal fungi (AMF) and endophytic fungi to promote growth and…
Molecular biology
Involvement of AKT/β-catenin in Enhanced Osteogenesis by Cannabidiol in Bone Stromal Cells Harvested from Human Tori
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-03763-5. Article type: Research Article Keywords: Ak strain transforming…
Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation
Abstract The persistence of HIV latent reservoir is the major challenge to HIV cure because latent viruses serve as sources…
Coordinated epigenetic dysregulation of CNR1 and FAAH genes drives endocannabinoid system dysfunction in anorexia nervosa
Abstract Background: Anorexia nervosa (AN) is a severe psychiatric disorder with limited biomarkers for diagnosis and treatment monitoring. We investigated…
Natural protection against oxidative stress in human skin melanocytes
Abstract Human skin plays a crucial role in protecting the body against environmental stressors. The skin cells involved in photoprotection…
DNA methylation profiles of long-term cannabis users in midlife: a comprehensive evaluation of published cannabis-associated methylation markers in a representative cohort
Abstract Epigenetic responses to cannabis use could link cannabis use to health problems. We examined the DNA-methylation profiles of long-term…
Cannabidiol reshapes the gut microbiome to promote endurance exercise in mice
Abstract Cannabidiol (CBD), a nonpsychoactive compound from Cannabis, has various bioactive functions in humans and animals. Evidence suggests that CBD…
Cannabidiol attenuates lipid metabolism and induces CB1 receptor-mediated ER stress associated apoptosis in ovarian cancer cells
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-88917-1. Article type: Research Article Keywords: Ovarian cancer, Lipid…
Methylomic signature of current cannabis use in two first-episode psychosis cohorts
Abstract The rising prevalence and legalisation of cannabis worldwide have underscored the need for a comprehensive understanding of its biological…
Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents
Abstract Background: The link between cannabis use and schizophrenia is well-established in epidemiological studies, especially among adolescents with early-onset use.…